Results 141 to 150 of about 28,217,704 (208)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Chiral Pyrazolinylidene Complexes for Asymmetric Catalysis

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
The synthesis and application of pyrazolin‐5‐ylidene NHC chiral‐at‐ruthenium catalysts is reported. The strong donating pyrazolin‐5‐ylidene ligands led to highly electron rich ruthenium complexes, which showed excellent catalytic activity and enantioselectivity in the intramolecular aziridination of an alkene.
Felix Möller   +6 more
wiley   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau   +3 more
wiley   +1 more source

Visible‐Light Cobalt‐Catalyzed Synthesis of Aroyl Amides From Arylazo Sulfones

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 20, 16 October 2026.
Blue Light and Cobalt Catalysis for Synthesis! A versatile strategy that combines photoactive arylazo sulfones as substrates and Co2(CO)8 as a catalyst for the preparation of aromatic amides is presented herein. A versatile strategy leveraging the peculiar reactivity of arylazo sulfones as substrates bearing dyedauxiliary groups in arylation processes,
Komal Jaiswal   +4 more
wiley   +1 more source

P‐Directed and Lewis Acid‐Assisted Pd‐Catalyzed Si─Me Bond Activation Enabling Alkyl Exchange at Silicon

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A new type of Si─Me bond activation enabling catalytic alkyl exchange at Si was developed. It involves a P‐directing group and Pd─Lewis acid cooperation. It enables the conversion of Me3SiCl into silanols with three different organic substituents. ABSTRACT A novel mode of Si─Me bond activation has been unveiled through the cooperative action of a P ...
Hajime Kameo   +5 more
wiley   +2 more sources

Functionalization of Peptides via Radical Arylation

open access: yesChemBioChem, Volume 27, Issue 19, 14 October 2026.
Radical chemistry has only rarely been applied to peptide functionalization. This short review highlights radical arylation as an attractive approach to access functionalized peptides under mild, biocompatible conditions without protecting groups.
Daniel R. Troeger, Markus R. Heinrich
wiley   +1 more source

Diversity‐Oriented Two‐Step Annulative π‐Extension Enables Access to Structurally Complex Nanographenes

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Pd‐catalyzed C–H arylation of polycyclic aromatic hydrocarbons (PAHs) with various aryltrimethylsilanes enables the preparation of structurally complicated arylated PAHs, which can be further transformed to nanographenes in a manner of two‐step annulative π‐extension (APEX) reaction.
Honami Katsuragawa   +5 more
wiley   +2 more sources

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