Results 121 to 130 of about 52,780 (297)

Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C-H bond functionalization

, 2013
Significant progress has been accomplished in direct olefinations through twofold C-H bond functionalization of arenes and heteroarenes employing readily accessible, selective and relatively inexpensive ruthenium catalysts.
Ackermann, Lutz, Kozhushkov, Sergei I.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

C–H Functionalization on Carbohydrates

, 2016
Functionalization of C–H bonds has received significant attention in organic chemistry during the last decade and it is still a “hot” topic. In particular, C–H modification of natural products has benefitted from this development.
Pedersen, Christian Marcus, Pedersen, C., Mikael Bols, Christian Marcus Pedersen, Frihed, Tobias Gylling, Frihed, T., Bols, Mikael, Tobias Gylling Frihed, Bols, M.   +8 more
core   +1 more source

Regioselective Pd-catalyzed direct C1- and C2-arylations of lilolidine for the access to 5,6-dihydropyrrolo[3,2,1-ij]quinoline derivatives

Beilstein Journal of Organic Chemistry, 2019
The Pd-catalyzed C–H bond functionalization of lilolidine was investigated. The use of a palladium-diphosphine catalyst associated to acetate bases in DMA was found to promote the regioselective arylation at α-position of the nitrogen atom of lilolidine ...
Hai-Yun Huang, Haoran Li, Thierry Roisnel, Jean-François Soulé, Henri Doucet   +4 more
doaj   +1 more source

Kobalta katalizēta C‒H saites funkcionalizēšana/Cobalt Catalyzed C‒H Bond Functionalization

, 2022
Lukass Lukasevics
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

sp2 Carbon-Hydrogen Bond (C-H) Functionalization [PDF]

, 2010
sp2 Carbon-Hydrogen Bond (C-H) FunctionalizationbySirilata YotphanDoctor of Philosophy in ChemistryUniversity of California, BerkeleyProfessor Robert G. Bergman, ChairChapter 1.
Yotphan, Sirilata
core  

Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions

, 2019
The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)–H bond functionalization (cross-dehydrogenative ...
Bondžić, Bojan, Džambaski, Zdravko
core   +1 more source

Unified metal-free intermolecular Heck-type sulfonylation, cyanation, amination, amidation of alkenes by thianthrenation

Nature Communications
Direct and site-selective C-H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules.
Ming-Shang Liu, Hai-Wu Du, Huan Meng, Ying Xie, Wei Shu   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source