Results 131 to 140 of about 27,304,717 (282)

Unified metal-free intermolecular Heck-type sulfonylation, cyanation, amination, amidation of alkenes by thianthrenation

Nature Communications
Direct and site-selective C-H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules.
Ming-Shang Liu, Hai-Wu Du, Huan Meng, Ying Xie, Wei Shu   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

sp2 Carbon-Hydrogen Bond (C-H) Functionalization [PDF]

, 2010
sp2 Carbon-Hydrogen Bond (C-H) FunctionalizationbySirilata YotphanDoctor of Philosophy in ChemistryUniversity of California, BerkeleyProfessor Robert G. Bergman, ChairChapter 1.
Yotphan, Sirilata
core  

C–H Functionalization on Carbohydrates

, 2016
Functionalization of C–H bonds has received significant attention in organic chemistry during the last decade and it is still a “hot” topic. In particular, C–H modification of natural products has benefitted from this development.
Pedersen, Christian Marcus, Pedersen, C., Mikael Bols, Christian Marcus Pedersen, Frihed, Tobias Gylling, Frihed, T., Bols, Mikael, Tobias Gylling Frihed, Bols, M.   +8 more
core   +1 more source

Understanding Precatalyst Activation and Speciation in Manganese-Catalyzed C-H Bond Functionalization Reactions. [PDF]

Organometallics, 2023
Eastwood JB, Hammarback LA, Burden TJ, Clark IP, Towrie M, Robinson A, Fairlamb IJS, Lynam JM.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

sp3 C–H Bond Functionalization with Ruthenium Catalysts

, 2014
International audienceThe selective formation of carbon–carbon bond by functionalization of an sp3C–H bond is still a challenge in organic synthesis. There are already examples involving transition metal catalysis.
Christian Bruneau, Bruneau, Christian
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Selective C-H Bond Functionalization of Pyrrolo[1,2-a]quinoxaline

<div style="text-align:justify;"> Pyrrolo[1,2-a]quinoxalines as important heterocyclic compounds have potential application in pharmaceuticals and synthesis due to their wide range of biological activities and pharmacological effects.
Yan Liu, Ping Liu, He Jing
core   +1 more source

C–H Trifluoromethylthiolation of aldehyde hydrazones

Beilstein Journal of Organic Chemistry
The selective C–H trifluoromethylthiolation of aldehyde hydrazones afforded interesting fluorinated building blocks, which could be used as a synthetic platform.
Victor Levet, Balu Ramesh, Congyang Wang, Tatiana Besset   +3 more
doaj   +1 more source