Results 131 to 140 of about 52,780 (297)

Understanding Precatalyst Activation and Speciation in Manganese-Catalyzed C-H Bond Functionalization Reactions. [PDF]

Organometallics, 2023
Eastwood JB, Hammarback LA, Burden TJ, Clark IP, Towrie M, Robinson A, Fairlamb IJS, Lynam JM.   +7 more
europepmc   +1 more source

Pd-catalyzed C-H bond functionalization of heterocycles and fluorobenzenes : a simple access to poly(hetero)aromatic compounds [PDF]

, 2021
Haiyun Huang
openalex  

Late-stage functionalization of 4-arylphthalazin-1(2H)-ones by a regioselective iridium-catalyzed C-H bond amidation reaction

, 2023
Huimin Li, Wenqing Lan, Ruohan Li, Jiang-Hua Li, Junmin Chen   +4 more
openalex   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

sp3 C–H Bond Functionalization with Ruthenium Catalysts

, 2014
International audienceThe selective formation of carbon–carbon bond by functionalization of an sp3C–H bond is still a challenge in organic synthesis. There are already examples involving transition metal catalysis.
Christian Bruneau, Bruneau, Christian
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Aromatic C-H bond functionalization through organocatalyzed asymmetric intermolecular aza-Friedel-Crafts reaction: a recent update. [PDF]

Beilstein J Org Chem, 2023
Biswas A.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Computational Studies of Metal Free C−H Bond Functionalization [PDF]

, 2020
Carbon–hydrogen bond functionalization reactions can greatly facilitate chemical synthesis due to their capability to increase molecular complexity from readily available starting materials with minimal waste generation.
Morales Rivera, Cristian A.
core