Results 151 to 160 of about 52,780 (297)

Combined C—H Functionalization/C—N Bond Formation Route to Carbazoles.

, 2006
W. C. Peter Tsang, Nan Zheng, Stephan L. Buchwald   +2 more
openalex   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

DFT Studies of Ru-Catalyzed C–O versus C–H Bond Functionalization of Aryl Ethers with Organoboronates

, 2017
Density functional theory calculations have been performed to investigate how different nucleophiles and directing groups affect the preference of C-H versus C-O bond functionalization in the ruthenium-catalyzed coupling reactions of aryl ethers with ...
Zheng Wang, Zhenyang Lin, Wai Han Lam, Zhou, Yu, Wang, Zheng, Lam, Wai Han, Yu Zhou, Lin, Zhenyang   +7 more
core   +1 more source

Condensation-Based Methods for the C-H Bond Functionalization of Amines. [PDF]

Synthesis (Stuttg), 2021
Chen W, Seidel D.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Diazo compounds as cross-coupling partners in C(sp2)-H bond functionalization

, 2022
Diazo compounds are undoubtedly among the most versatile classes of organic compounds. Thanks to their ability to serve as either carbene precursors or 1,3-dipoles, they have traditionally been used in a broad array of useful transformations including ...
Maura Marinozzi, Lorenzo Pontini, Tommaso Angelini   +2 more
core  

Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. [PDF]

J Am Chem Soc, 2023
Ren X, Couture BM, Liu N, Lall MS, Kohrt JT, Fasan R.   +5 more
europepmc   +1 more source

Frontispiece: Steering Site‐Selectivity in Transition Metal‐Catalyzed C−H Bond Functionalization: the Challenge of Benzanilides [PDF]

, 2020
Rafael Gramage‐Doria
openalex   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Rieske Oxygenase Catalyzed C-H Bond Functionalization Reactions in Chlorophyll b Biosynthesis. [PDF]

ACS Cent Sci, 2022
Liu J, Knapp M, Jo M, Dill Z, Bridwell-Rabb J.   +4 more
europepmc   +1 more source