Results 51 to 60 of about 29,179,465 (256)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Type of Aromatic π‐Systems for Anion Recognition: Strong Anion‐π and C−H⋅⋅⋅Anion Interactions Between Halides and Aromatic Ligands in Half‐Sandwich Compounds

, 2021
Half-sandwich compounds of benzene, cyclopentadienyl, pentamethylcyclopentadienyl, and indenyl were studied as a new type of aromatic π-systems for interactions with halide anions.
Malenov, Dušan, Zarić, Snežana D., Snežana D. Zarić, Dušan P. Malenov   +3 more
core   +1 more source

Crystal structure of N,N′-bis[2-((benzyl){[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)ethyl]naphthalene-1,8:4,5-tetracarboximide 1,2-dichlorobenzene trisolvate

Acta Crystallographica Section E: Crystallographic Communications, 2016
The asymmetric unit of the title compound, C56H50N6O8S2·3C6H4Cl2, contains two half-molecules of the parent, A and B, which both have crystallographic inversion symmetry, together with three 2,3-dichlorobenzene molecules of solvation.
Miguel Ángel Claudio-Catalán, Felipe Medrano, Hugo Tlahuext, Carolina Godoy-Alcántar   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Coordination polymers utilizing N-oxide functionalised host ligands [PDF]

, 2012
Pyridyl functionalized host molecules are oxidized to their N-oxide analogues and form a series of coordination polymers and discrete complexes with transition metal cations.
Hardie, Michaele J., Barnett, S.A., James J. Henkelis, Sarah A. Barnett, Harding, L.P., Hardie, M.J., Henkelis, James J., Michaele J. Hardie, Barnett, Sarah A., Henkelis, J.J., Lindsay P. Harding, Harding, Lindsay P.   +11 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

N′-[(1Z)-1-(3-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidene)ethyl]-2-[(4-methylphenyl)sulfanyl]acetohydrazide

IUCrData, 2017
In the title compound, C21H22N4O2S, the dihedral angle between the pyrazole ring and adjacent benzene ring is 6.4 (1)°. The molecular conformation is influenced by intramolecular N—H...O and C—H...O hydrogen bonds.
Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Mohamed S. Abbady, Etify A. Bakhite, Mustafa R. Albayati   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Transformations of Griseofulvin in Strong Acidic Conditions – Crystal Structures of 2′-Demethylgriseofulvin and Dimerized Griseofulvin

Natural Product Communications, 2012
The structure of griseofulvic acid, C 16 H 15 ClO 6 , at 100 K has orthorhombic (P2 1 2 1 2) symmetry. It is of interest with respect to biological activity.
Barbara Lesniewska, Said Jebors, Anthony W. Coleman, Kinga Suwińska   +3 more
doaj   +1 more source

Crystal structure of bis(4-methoxyphenyl) malonate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The complete molecule of the title compound, C17H16O6, is generated by crystallographic twofold symmetry, with the central methylene C atom lying on the rotation axis.
H. C. Devarajegowda, P. A. Suchetan, S. Sreenivasa, H. T. Srinivasa, B. S. Palakshamurthy   +4 more
doaj   +1 more source