Results 71 to 80 of about 598,727 (266)

Transformations of Griseofulvin in Strong Acidic Conditions – Crystal Structures of 2′-Demethylgriseofulvin and Dimerized Griseofulvin

Natural Product Communications, 2012
The structure of griseofulvic acid, C 16 H 15 ClO 6 , at 100 K has orthorhombic (P2 1 2 1 2) symmetry. It is of interest with respect to biological activity.
Barbara Lesniewska, Said Jebors, Anthony W. Coleman, Kinga Suwińska   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Crystal structure of bis(4-methoxyphenyl) malonate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The complete molecule of the title compound, C17H16O6, is generated by crystallographic twofold symmetry, with the central methylene C atom lying on the rotation axis.
H. C. Devarajegowda, P. A. Suchetan, S. Sreenivasa, H. T. Srinivasa, B. S. Palakshamurthy   +4 more
doaj   +1 more source

Enhanced photochemical oxidation ability of carbon nitride by π–π stacking interactions with graphene [PDF]

, 2017
A one-pot method for the preparation of g-C3N4/reduced graphene oxide (rGO) composite photocatalysts with controllable band structures is presented.
Xun Li, Ding, Hao, Li, Xun, Chen, Daimei, Daimei Chen, Hao, Qiang, Hao Ding, Niu, Xiuxiu, Qiang Hao, Xiuxiu Niu, Simeng Hao, Hao, Simeng   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Self-Assembly and (Hydro)gelation Triggered by Cooperative π–π and Unconventional C[BOND]H⋅⋅⋅X Hydrogen Bonding Interactions [PDF]

, 2013
Weak C[BOND]H⋅⋅⋅X hydrogen bonds are important stabilizing forces in crystal engineering and anion recognition in solution. In contrast, their quantitative influence on the stabilization of supramolecular polymers or gels has thus far remained unexplored.
Stepanenko, V., Mayoral, Maria Jose, Rest, Christina, Edkins, Katharina, Fucke, K., Fernández, G., Fernandez, Gustavo, Rest, C., Schellheimer, Jennifer, Stepanenko, Vladimir, Mayoral, M.J., Shellheimer, J.   +11 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Crystal structures of 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene

Acta Crystallographica Section E: Crystallographic Communications, 2019
Two thiochromene compounds containing Br and F atoms, namely 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene (C17H13BrFNO3S, A) and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene (C16H11BrFNO3S, B), were prepared via the ...
Chien Thang Pham, Dinh Hung Mac, Thai Thanh Thu Bui   +2 more
doaj   +1 more source

Study of C−H⋅⋅⋅π interactions with pyrrole and chelate rings in metal-porphyrin complexes [PDF]

, 2006
The Cambridge Structural Database (CSD) was screened in order to find and investigate specific C−H⋅⋅⋅π interactions between C−H groups and two types of rings with delocalized π-bonds that exist in porphyrin: pyrrole and six-membered chelate.
Medaković, Vesna B., Milčić, Miloš K., Bogdanović, Goran A.   +2 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source