Results 61 to 70 of about 469,634 (251)

N′-[(1Z)-1-(3-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidene)ethyl]-2-[(4-methylphenyl)sulfanyl]acetohydrazide

IUCrData, 2017
In the title compound, C21H22N4O2S, the dihedral angle between the pyrazole ring and adjacent benzene ring is 6.4 (1)°. The molecular conformation is influenced by intramolecular N—H...O and C—H...O hydrogen bonds.
Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Mohamed S. Abbady, Etify A. Bakhite, Mustafa R. Albayati   +5 more
doaj   +1 more source

Crystal Structure of Ethyl 2-(2-fluorobenzylidene)-5-(4-fluorophenyl)-7-Methyl-3-Oxo-2,3-Dihydro-5H-1,3-Thiazolo[3,2-A]pyrimidine-6-Carboxylate [PDF]

, 2014
In the title molecule, C23H18F2N2O3S, the 4-fluoro-substituted and 2-fluoro-substituted benzene rings form dihedral angles of 88.16 (8) and 23.1 (1)°, respectively, with the thiazole ring. The pyrimidine ring adopts a flattened sofa conformation with the
Krishnamurthy, M.S., Noor Shahina Begum, .   +1 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Different supramolecular interactions mediated by bromine atoms in the crystal structures of three anisole derivatives [PDF]

, 2018
Three anisole building blocks featuring bishydroxymethyl or bisbromomethyl pendants have been analyzed with regard to their molecular structure and packing behaviour. A typical supramolecular pattern we found were C—H···π interactions responsible for the
Gruber, Tobias, Nestler, Robert, Schwarzer, Anke   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

2-(10-Bromoanthracen-9-yl)-N-phenylaniline

IUCrData
In the title compound, C26H18BrN, the central benzene ring makes dihedral angles with its adjacent anthracene ring system and pendant benzene ring of 87.49 (13) and 62.01 (17)°, respectively.
Dhandayutham Saravanan, C. Ponraj, Themmila Khamrang, Madhukar Hemamalini, G. Jerald Maria Antony   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

6-Bromo-9,9-diethyl-N,N-diphenylfluoren-2-amine

IUCrData
In the title compound, C29H26BrN, the dihedral angles between the fluorene fused-ring system and the pendant phenyl groups are 67.76 (12) and 88.38 (12)°. In the crystal, weak pairwise C—H...π interactions link the molecules into inversion dimers.
Themmila Khamrang, A. Kannan, C. Ponraj, Madhukar Hemamalini, G. Jerald Maria Antony, Dhandayutham Saravanan   +5 more
doaj   +1 more source

Crystal structures of 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene

Acta Crystallographica Section E: Crystallographic Communications, 2019
Two thiochromene compounds containing Br and F atoms, namely 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene (C17H13BrFNO3S, A) and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene (C16H11BrFNO3S, B), were prepared via the ...
Chien Thang Pham, Dinh Hung Mac, Thai Thanh Thu Bui   +2 more
doaj   +1 more source

Intermolecular O-H...O and C-H...π(C5H5), and intramolecular C-H...O interactions in 2-(ferrocenyl)thiophene-3-carboxylic acid [PDF]

, 2001
The title compound, [Fe(C₅H₅)(C₁₀H₇O₂S)], an important precursor en route to organometallic donor-π-acceptor systems, forms dimers in the solid state through cyclic intermolecular carboxylic acid O-H...O hydrogen bonds, graph set R²₂(8) [O...O 2.661 (2)
Gallagher, John F., Hudson, Richard D.A., Manning, Anthony R.   +2 more
core   +1 more source