Results 1 to 10 of about 666,443 (307)

C-C chemokine receptor type 6 modulates the biological function of osteoblastogenesis by altering the expression levels of Osterix and OPG/RANKL

BioScience Trends, 2021
Circulating inflammatory factors affect osteoblast and osteoclast formation and activity in osteoporosis. Estrogen affects the migration of Th17 cells via the C-C chemokine receptor type 6 (CCR6) and C-C chemokine ligand 20 (CCL20) signaling pathways to modulate bone metabolism; however, it is unclear whether and how CCR6 modulates bone homeostasis. In
Zengshu Huang, Jing Zhou, Na Zhang, Ling Wang, Xuemin Qiu, Lisha Li, Yingping Xu   +6 more
semanticscholar   +7 more sources

Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T‐Cell‐Directed Therapies

Advanced Science, 2021
Gluten‐specific CD4+ T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T‐cell‐directed therapy can change with time and upon activation in CeD and other autoimmune ...
Asbjørn Christophersen, Stephanie Zühlke, Eivind G. Lund, Omri Snir, Shiva Dahal‐Koirala, Louise Fremgaard Risnes, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +8 more
doaj   +2 more sources

Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats.

PLoS ONE, 2022
It is known that exercise can be one of the causes of muscular damage. In recent times, physiotherapists and medical professionals have been employing USGET techniques to stimulate muscle recovery to improve its performance after the injury.
Adrian Jorda, Juan Campos-Campos, Constanza Aldasoro, Carlos Colmena, Martin Aldasoro, Kenia Alvarez, Soraya L Valles   +6 more
doaj   +2 more sources

An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice [PDF]

, 2011
Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection.
Barth, Thomas, Botteron, Catherine, Lechner, Anja, Männel, Daniela N., Nguyen, Trang T. T., Ritter, Uwe, Schmidt, Dominic   +6 more
core   +13 more sources

Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN/GS/2018 strain

Virology Journal, 2021
Background African swine fever virus (ASFV) is a highly lethal virus that can infect porcine alveolar macrophages (PAMs). Since ASFV, China has dealt with a heavy blow to the pig industry.
Bo Yang, Chaochao Shen, Dajun Zhang, Ting Zhang, Xijuan Shi, Jinke Yang, Yu Hao, Dengshuai Zhao, Huimei Cui, Xingguo Yuan, Xuehui Chen, Keshan Zhang, Haixue Zheng, Xiangtao Liu   +13 more
doaj   +1 more source

Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

Journal for ImmunoTherapy of Cancer, 2020
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact with other immune cells to build a coordinated antitumor immune response.
Diane Damotte, Laurence Zitvogel, Marco Alifano, Marie-Caroline Dieu-Nosjean, Gabriela Bindea, Jeremy Goc, Jules Russick, Pierre-Emmanuel Joubert, Mélanie Gillard-Bocquet, Carine Torset, Maxime Meylan, Florent Petitprez, Marie-Agnes Dragon-Durey, Solenne Marmier, Aditi Varthaman, Nathalie Josseaume, Claire Germain, Pierre Validire, Ludovic Fournel, Audrey Lupo, Isabelle Cremer   +20 more
doaj   +1 more source

Cellular and Molecular Mechanisms and Effects of Berberine on Obesity-Induced Inflammation

Biomedicines, 2022
Obesity represents chronic low-grade inflammation that precipitates type 2 diabetes, cardiovascular disease, and cancer. Berberine (BBR) has been reported to exert anti-obesity and anti-inflammatory benefits. We aimed to demonstrate the underlying immune-
Ji-Won Noh, Min-Soo Jun, Hee-Kwon Yang, Byung-Cheol Lee   +3 more
doaj   +1 more source

Effects of deoxynivalenol- and zearalenone-contaminated feed on the gene expression profiles in the kidneys of piglets [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN), common contaminants in the feed of farm animals, cause immune function impairment and organ inflammation.
Kondreddy Eswar Reddy, Woong Lee, Jin young Jeong, Yookyung Lee, Hyun-Jeong Lee, Min Seok Kim, Dong-Woon Kim, Dongjo Yu, Ara Cho, Young Kyoon Oh, Sung Dae Lee   +10 more
doaj   +1 more source

Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage

Virulence, 2021
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao, Zheng Chen   +5 more
doaj   +1 more source

Methylated (−)-epigallocatechin 3-O-gallate potentiates the effect of split vaccine accompanied with upregulation of Toll-like receptor 5

Scientific Reports, 2021
Split-virus vaccine serves as a major countermeasure against influenza virus, but its effectiveness and protective action are not complete. We previously demonstrated the effect of Benifuuki, a green tea cultivar in Japan, on enhancing the split-virus ...
Motofumi Kumazoe, Kanako Takamatsu, Fuyumi Horie, Ren Yoshitomi, Hiroki Hamagami, Hiroshi Tanaka, Yoshinori Fujimura, Hirofumi Tachibana   +7 more
doaj   +1 more source