Results 11 to 20 of about 666,443 (307)

Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. [PDF]

PLoS ONE, 2011
BACKGROUND:Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.
Qun Li, Fang Ke, Weiwei Zhang, Xiaoyan Shen, Qiannan Xu, Hong Wang, Xue-Zhong Yu, Qibin Leng, Honglin Wang   +8 more
doaj   +2 more sources

C-X-C Chemokine Receptor Type 6 [PDF]

Definitions, 2020

openalex   +2 more sources

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Nature Biomedical Engineering, 2021
The efficacy of adoptive cell therapy for solid tumours is hampered by the poor accumulation of the transferred T cells in tumour tissue. Here, we show that forced expression of C-X-C chemokine receptor type 6 (whose ligand is highly expressed by human ...
Stefanie Lesch, Viktoria Blumenberg, Stefan Stoiber, Adrian Gottschlich, Justyna Ogonek, Bruno L. Cadilha, Zahra Dantes, Felicitas Rataj, Klara Dorman, Johannes Lutz, Clara H. Karches, Constanze Heise, Mathias Kurzay, Benjamin M. Larimer, G Simon, Moritz Rapp, Alessia Nottebrock, Stephan Krüger, Nicholas Tokarew, Philipp Metzger, Christine Hoerth, Mohamed-Reda Benmebarek, Dario Dhoqina, Ruth Grünmeier, Matthias Seifert, Arman Oener, Öykü Umut, Sandy Joaquina, Lene Vimeux, Thi Tran, Thomas Hank, Taisuke Baba, Duc Huynh, Remco T. A. Megens, Klaus-Peter Janßen, Martin Jastroch, Daniel Lamp, Svenja Ruehland, Mauro Di Pilato, Jasper N. Pruessmann, Moritz Thomas, Carsten Marr, Steffen Ormanns, Anna Reischer, Michael Hristov, Éric Tartour, Emmanuel Donnadieu, Simon Rothenfußer, Peter Duewell, Lars M. König, Max Schnurr, Marion Subklewe, Andrew S. Liss, Niels Halama, Maximilian Reichert, Thorsten R. Mempel, Stefan Endres, Sebastian Kobold   +57 more
openalex   +3 more sources

Hepatic C-X-C chemokine receptor type 6–expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury

Hepatology Communications, 2023
Background: Acute liver failure (ALF) is characterized by rapid clinical deterioration and high mortality. Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with subsequent inflammation ...
Felix Heymann, Jana C. Mossanen, Moritz Peiseler, Patricia M. Niemietz, Bruna Araújo David, Oliver Krenkel, Anke Liepelt, Matheus Batista Heitor Carneiro, Marlene Kohlhepp, Paul Kubes, Frank Tacke   +10 more
openalex   +2 more sources

C-C chemokine receptor 2 inhibitor ameliorates hepatic steatosis by improving ER stress and inflammation in a type 2 diabetic mouse model. [PDF]

PLoS ONE, 2015
Hepatic steatosis is the accumulation of excess fat in the liver. Recently, hepatic steatosis has become more important because it occurs in the patients with obesity, type 2 diabetes, and hyperlipidemia and is associated with endoplasmic reticulum (ER ...
Hong-Min Kim, Eun Soo Lee, Bo Ra Lee, Dhananjay Yadav, You Mi Kim, Hyun-Jeong Ko, Kyu Sang Park, Eun Young Lee, Choon Hee Chung   +8 more
doaj   +2 more sources

Role of CXCL16 in BLM-induced epithelial–mesenchymal transition in human A549 cells

Respiratory Research, 2021
Alveolar epithelial cells play an essential role in the initiation and progression of pulmonary fibrosis, and the occurrence of epithelial–mesenchymal transition (EMT) may be the early events of pulmonary fibrosis.
Zhenzhen Ma, Chunyan Ma, Qingfeng Zhang, Yang Bai, Kun Mu, Xiangyuan Liu, Qingrui Yang   +6 more
doaj   +1 more source

Age-dependent alterations in the immunoreactivity of macrophage inflammatory protein-3α and its receptor CCR6 in the gerbil hippocampus

Molecular Medicine Reports, 2020
Neuroinflammation is a primary characteristic of the aging brain. During normal aging, macrophage inflammatory protein-3α (MIP-3α) and its receptor C-C chemokine receptor type 6 (CCR6) serve pivotal roles in the neuroinflammatory process in the brain ...
J. Ahn, J. Park, Tae-Kyung Lee, G. Yang, M. Shin, J. Cho, M. Won, Choong Hyun Lee   +7 more
semanticscholar   +1 more source

Transcriptome-wide analysis of differentially expressed chemokine receptors, SNPs, and SSRs in the age-related macular degeneration

Human Genomics, 2019
Background Age-related macular degeneration (AMD) is the most common, progressive, and polygenic cause of irreversible visual impairment in the world. The molecular pathogenesis of the primary events of AMD is poorly understood.
Madhu Sudhana Saddala, Anton Lennikov, Anthony Mukwaya, Lijuan Fan, Zhengmao Hu, Hu Huang   +5 more
doaj   +1 more source

MicroRNA-183 attenuates osteoarthritic pain by inhibiting the TGFα-mediated CCL2/CCR2 signalling axis

Bone & Joint Research, 2021
Aims: MicroRNA-183 (miR-183) is known to play important roles in osteoarthritis (OA) pain. The aims of this study were to explore the specific functions of miR-183 in OA pain and to investigate the underlying mechanisms.
Zirong Tao, Yang Zhou, Biyun Zeng, Xucheng Yang, Manman Su   +4 more
doaj   +1 more source

The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. [PDF]

, 2017
In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS).
Atasoy, Ulus, Chen, Jing, Cramer, Carole, Drew, Paul D., Gorospe, Myriam, Martindale, Jennifer L., Yu, Shiguang   +6 more
core   +2 more sources