Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT. [PDF]
PLoS Pathogens, 2012 The second messenger, cyclic diguanylate (c-di-GMP), regulates diverse cellular processes in bacteria. C-di-GMP is produced by diguanylate cyclases (DGCs), degraded by phosphodiesterases (PDEs), and receptors couple c-di-GMP production to cellular ...
Nicholas J Shikuma +2 more
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Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch [PDF]
Molecules, 2012 C-di-GMP, a cyclic guanine dinucleotide, has been shown to regulate biofilm formation as well as virulence gene expression in a variety of bacteria. Analogues of c-di-GMP have the potential to be used as chemical probes to study c-di-GMP signaling and ...
Herman O. Sintim +4 more
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A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli [PDF]
Frontiers in ChemistryCyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence.
He Li +4 more
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Integration of the Second Messenger c-di-GMP into the Chemotactic Signaling Pathway [PDF]
mBio, 2013 Elevated intracellular levels of the bacterial second messenger c-di-GMP are known to suppress motility and promote sessility. Bacterial chemotaxis guides motile cells in gradients of attractants and repellents over broad concentration ranges, thus ...
Matthew H. Russell +6 more
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Functional Specialization in
mBio, 2019 Vibrio cholerae biofilm formation and associated motility suppression are correlated with increased concentrations of cyclic diguanylate monophosphate (c-di-GMP), which are in turn driven by increased levels and/or activity of diguanylate cyclases (DGCs).
David Zamorano-Sánchez +7 more
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Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems [PDF]
Cell Communication and Signaling, 2023 Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in many bacterial species, where it functions as a nucleotide-based secondary messenger and is a vital regulator of numerous biological processes.
Fazlurrahman Khan +3 more
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A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP [PDF]
Nature CommunicationsCyclic diguanosine monophosphate (c-di-GMP) functions as a crucial bacterial second messenger to control diverse biological functions. Although numerous studies have reported the health effects of Lactiplantibacillus plantarum, the regulatory role of c ...
Quan Guo +6 more
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Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism [PDF]
Cell ReportsSummary: Cyclic di-guanosine monophosphate (c-di-GMP) is a bacterial second messenger that governs the lifestyle switch between planktonic and biofilm states.
Corey Kennelly +2 more
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PLoS ONE, 2011 Upon Salmonella enterica serovar Typhimurium infection of the gut, an early line of defense is the gastrointestinal epithelium which senses the pathogen and intrusion along the epithelial barrier is one of the first events towards disease.
Irfan Ahmad +7 more
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A deterministic, c-di-GMP-dependent program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis [PDF]
Nature CommunicationsPhenotypic heterogeneity in bacteria can result from stochastic processes or deterministic programs. The deterministic programs often involve the versatile second messenger c-di-GMP, and give rise to daughter cells with different c-di-GMP levels by ...
María Pérez-Burgos +7 more
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