Results 1 to 10 of about 459,023 (174)

The global regulation of c-di-GMP and cAMP in bacteria. [PDF]

mLife
AbstractNucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria. The best‐studied examples are cyclic AMP (cAMP) and bis‐(3′–5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP), which both act as global regulators.
Liu C, Shi R, Jensen MS, Zhu J, Liu J, Liu X, Sun D, Liu W.   +7 more
europepmc   +5 more sources

Polarity of c-di-GMP synthesis and degradation. [PDF]

Microlife, 2023
AbstractThe bacterial cell pole has long been recognized as a defined compartment for enzymatic activities that are important or even vital for the cell. Polarity of diguanylate cyclases and phosphodiesterases, enzymes that synthesize and degrade the second messenger c-di-GMP, has now been demonstrated for several bacterial systems.
Kreiling V, Thormann KM.
europepmc   +4 more sources

OpaR Controls the Metabolism of c-di-GMP in Vibrio parahaemolyticus [PDF]

Frontiers in Microbiology, 2021
Vibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis worldwide, has a strong ability to form biofilms on surfaces. Quorum sensing (QS) is a process widely used by bacteria to communicate with each other and control gene expression via the secretion and detection of autoinducers.
Yiquan Zhang, Yue Qiu, He Gao, Junfang Sun, Xue Li, Miaomiao Zhang, Xingfan Xue, Wenhui Yang, Bin Ni, Lingfei Hu, Zhe Yin, Renfei Lu, Dongsheng Zhou   +12 more
semanticscholar   +6 more sources

Polymorphism of the Signaling Molecule c-di-GMP [PDF]

Journal of the American Chemical Society, 2006
Using UV, CD, and NMR, we demonstrate that the important bacterial signaling molecule involved in biofilm formation, cyclic diguanosine monophosphate (c-di-GMP), exists as a mixture of five different but related structures in an equilibrium that is sensitive both to its concentration and to the metal present. At the lower concentrations used for UV and
Zhaoying Zhang, Seho Kim, Barbara L. Gaffney, Roger A. Jones   +3 more
openalex   +4 more sources

Bacterial c-di-GMP has a key role in establishing host-microbe symbiosis. [PDF]

Nat Microbiol, 2023
Most microbes evolve faster than their hosts and should therefore drive evolution of host–microbe interactions. However, relatively little is known about the characteristics that define the adaptive path of microbes to host association.
Obeng N, Czerwinski A, Schütz D, Michels J, Leipert J, Bansept F, García García MJ, Schultheiß T, Kemlein M, Fuß J, Tholey A, Traulsen A, Sondermann H, Schulenburg H.   +13 more
europepmc   +2 more sources

Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems. [PDF]

Cell Commun Signal, 2023
Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in many bacterial species, where it functions as a nucleotide-based secondary messenger and is a vital regulator of numerous biological processes.
Khan F, Jeong GJ, Tabassum N, Kim YM.
europepmc   +2 more sources

Multiple activities of c-di-GMP in Pseudomonas aeruginosa [PDF]

Nucleic Acids Symposium Series, 2009
Survival strategies of many bacterial pathogens, including Pseudomonas aeruginosa, are linked to their ability to form surface associated communities called biofilms. The biofilm life style allows these organisms to persist in various tissues, avoid clearance by innate host defences and significantly enhanced their resistance to antibiotics.
Stephen Lory, Massimo Merighi, Mamoru Hyodo   +2 more
openalex   +4 more sources

c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella. [PDF]

Nat Commun, 2023
Cyclic di-GMP (c-di-GMP) is a second messenger that transduces extracellular stimuli into cellular responses and regulates various biological processes in bacteria. H-NS is a global regulatory protein that represses expression of many genes, but how H-NS
Li S, Liu Q, Duan C, Li J, Sun H, Xu L, Yang Q, Wang Y, Shen X, Zhang L.   +9 more
europepmc   +2 more sources

Gas and light: triggers of c-di-GMP-mediated regulation. [PDF]

FEMS Microbiol Rev, 2023
The widespread bacterial second messenger c-di-GMP is responsible for regulating many important physiological functions such as biofilm formation, motility, cell differentiation, and virulence. The synthesis and degradation of c-di-GMP in bacterial cells
Yu Z, Zhang W, Yang H, Chou SH, Galperin MY, He J.   +5 more
europepmc   +2 more sources

A c-di-GMP binding effector controls cell size in a cyanobacterium. [PDF]

Proc Natl Acad Sci U S A, 2023
Significance Cell size homeostasis is an essential physical trait of bacteria, and how the cell size is maintained and regulated remains an important question in microbiology.
Zeng X, Huang M, Sun QX, Peng YJ, Xu X, Tang YB, Zhang JY, Yang Y, Zhang CC.   +8 more
europepmc   +2 more sources