c-di-GMP Inhibits Early Sporulation in Clostridioides difficile [PDF]
mSphere, 2021 The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C.
Adrianne N. Edwards +4 more
doaj +3 more sources
Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems
Cell Communication and Signaling, 2023 Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in many bacterial species, where it functions as a nucleotide-based secondary messenger and is a vital regulator of numerous biological processes.
Fazlurrahman Khan +3 more
doaj +2 more sources
c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR [PDF]
mBioAs a near-ubiquitous bacterial second messenger, cyclic di-GMP (c-di-GMP) regulates a multitude of important biological processes. The regulatory effects of c-di-GMP on bacterial physiological processes are mediated through its interaction with various ...
Lianying Mao +7 more
doaj +2 more sources
The global regulation of c-di-GMP and cAMP in bacteria. [PDF]
mLifeNucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria. The best‐studied examples are cyclic AMP (cAMP) and bis‐(3′–5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP ...
Liu C +7 more
europepmc +2 more sources
Polarity of c-di-GMP synthesis and degradation
microLife, 2023 The bacterial cell pole has long been recognized as a defined compartment for enzymatic activities that are important or even vital for the cell. Polarity of diguanylate cyclases and phosphodiesterases, enzymes that synthesize and degrade the second ...
Vanessa Kreiling, K. Thormann
semanticscholar +3 more sources
Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation [PDF]
PLOS Genetics, 2020 The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle.
Daniel C Wu +10 more
semanticscholar +6 more sources
Gas and light: triggers of c-di-GMP-mediated regulation.
FEMS Microbiology Reviews, 2023 AbstractThe widespread bacterial second messenger c-di-GMP is responsible for regulating many important physiological functions such as biofilm formation, motility, cell differentiation, and virulence. The synthesis and degradation of c-di-GMP in bacterial cells depend, respectively, on diguanylate cyclases and c-di-GMP-specific phosphodiesterases ...
Zhao-Yun Yu +5 more
semanticscholar +3 more sources
A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli [PDF]
Frontiers in ChemistryCyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence.
He Li +4 more
doaj +2 more sources
Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors [PDF]
BiomoleculesCyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia +11 more
doaj +2 more sources
Low levels of the second messenger c-di-GMP enhance tolerance and resistance to meropenem in Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundThe carbapenem antibiotic meropenem is often used to treat life-threatening infections caused by Pseudomonas aeruginosa. Previous studies have shown that the susceptibility of P.
Tarcisio Brignoli +4 more
doaj +2 more sources