Results 141 to 150 of about 17,904 (252)

A dual-threshold system relying on multiple c-di-GMP metabolic enzymes controls cell fate of a cyanobacterium. [PDF]

PLoS Biol
Sun QX, Huang M, Yang Y, Zeng X, Zhang CC.   +4 more
europepmc   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species. [PDF]

FEMS Microbiol Rev
Vondrova D, Mugni SL, Blumenstein J, Kasiztky C, Sisti F, Fernández J, Kamanova J.   +6 more
europepmc   +1 more source

Simple Guanosine—Amino Acid Hybrids as Low Molecular Weight Hydrogelators

Chemistry – A European Journal, EarlyView.
Unexplored guanosine‐amino acid derivatives act as low molecular weight hydrogelators. Gelation is triggered by K+ ions and pH changes and relies on G‐quadruplex formation. Small changes in the amino acid structure have a strong impact on the mechanical properties of the gels.
Silvia Pieraccini, Samuele Ruffoli, Martina Occhi, Demetra Giuri, Devis Montroni, Claudia Tomasini, Stefano Masiero   +6 more
wiley   +1 more source

Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation. [PDF]

PLoS Genet
Cınar Cakmak B, Saric JD, Wrede K, Holmes NA, Haist J, Schumacher MA, Buttner MJ, Tschowri N.   +7 more
europepmc   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

<i>Azotobacter vinelandii</i> AmrZ is a global regulator linking alginate production and c-di-GMP homeostasis. [PDF]

Microbiology (Reading)
Gonzaga-Pérez MC, Ahumada-Manuel CL, Chávez-Martínez AI, Guzman J, Estrada K, Espín G, Núñez C.   +6 more
europepmc   +1 more source

Digital Transformation of Medicines Regulation in Africa—Perspectives from a Stakeholder Convening

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory authorities worldwide are developing strategies to integrate artificial intelligence (AI) into the lifecycle of health products, technologies, and medicines. While regulators share goals of improving efficiency, strengthening decision‐making, and protecting public health, their approaches differ according to institutional structures ...
Christelna Reyneke, Boitumelo Semete‐Makokotlela, Varnika Singh, Khanyisile Nkuku, Madelein Terblanche, Ezekiel T Mukanga, Nancy Ngum, Kudakwashe Dandajena, McNeil Chimus Mhango, Paulyne Wairimu, John Mwangi, Dominique Lagrave, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

Social Accounting for Work‐Related Injuries: Towards a Sustainable Management of Social Externalities

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The present study seeks to advance the understanding of the determinants of occupational injuries, thereby enhancing both academic knowledge and decision‐making in the management and implementation of occupational health and safety measures.
Rosa María Cañaveras Perea, Ángel Tejada Ponce, María Pilar Sánchez González   +2 more
wiley   +1 more source

Local c-di-GMP signaling, triggered by cross-regulation of cAMP-CRP and c-di-GMP, controls biofilm formation under nutrient limitation. [PDF]

Proc Natl Acad Sci U S A
Sun D, Liu X, Zhang Y, Shi R, Ru Y, Zhou X, Chen Y, Yang J, Liu J, Zhu J, Liu C, Liu W.   +11 more
europepmc   +1 more source