Results 121 to 130 of about 31,009,639 (254)

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

MshE binds c-di-GMP.

, 2015
A. Isothermal Calorimetry was performed on purified proteins to determine the binding affinity for c-di-GMP. Three independent runs were included in the analysis, one representative run is depicted.
Andrew Utada (818848), Vinita Banakar (818851), Christopher J. Jones (531373), Lynette Cegelski (816292), Wiriya Thongsomboon (818849), Kimberly R. Davis (231763), Fitnat H. Yildiz (162562), David Zamorano Sanchez (818850), Gerard C. L. Wong (231765)   +8 more
core   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Optogenetic Module for Dichromatic Control of c-di-GMP Signaling

, 2017
Many aspects of bacterial physiology and behavior, including motility, surface attachment, and the cell cycle, are controlled by cyclic di-GMP (c-di-GMP)-dependent signaling pathways on the scale of seconds to minutes.
Mark Gomelsky, Min-Hyung Ryu, Oleg V. Moskvin, Anastasia Fomicheva   +3 more
core   +1 more source

Ultrasound‐Activated Ce(IV)‐Integrated Biomimetic Nanoplatform for Oxygenation‐Reinforced Gas‐Sonodynamic Ferroptosis and cGAS–STING‐Driven Antitumor Immunity

Advanced Science, EarlyView.
A Ce(IV)‐integrated biomimetic nanoplatform coordinates tumor oxygenation, ultrasound‐triggered carbon monoxide release, sonodynamic therapy, ferroptosis amplification, and cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) immune activation.
Mengli Ma, Yingying Wu, Yunjie Wang, Yang Li, Yijia Zhang, Zhibo Zhang, Jinzhi Peng, Xiangyu Wu, Yi Luo, Weijing Zhang, Xin Ye, Weisong Lai, Shengyu Wang, Dan Du, Wengang Li, Nan Zheng, Fanghong Luo, Ting Wu   +17 more
wiley   +1 more source

Table_1_Functional Characterization of c-di-GMP Signaling-Related Genes in the Probiotic Lactobacillus acidophilus.docx

, 2018
The bacterial second messenger cyclic diguanylate monophosphate (c-di-GMP) regulates a series of cellular functions, including biofilm formation, motility, virulence, and other processes.
Jiahui He (5696630), Jieli Sun (5696636), Fang Wang (105926), Wenjuan Yan (561252), Wenhao Ruan (5696633)   +4 more
core   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Diverse Biological Functions and Domain-Specific Interactions of the Diguanylate Cyclase PA2072 in Pseudomonas aeruginosa PAO1

International Journal of Microbiology
Nucleotide bis-(3,5)-cyclic di-guanosine monophosphate (c-di-GMP) is a universal and versatile secondary messenger. It is involved in the regulation of significant functions such as motility, biofilm formation, virulence, drug resistance, cell cycle ...
Xiaojing Gao, Yan Zhang, Lingna Guo, Huimin Zhang, Jianwen Sun, Jianfang Sun, Weidong Huang   +6 more
doaj   +1 more source

Image_1_Functional Characterization of c-di-GMP Signaling-Related Genes in the Probiotic Lactobacillus acidophilus.jpg

, 2018
The bacterial second messenger cyclic diguanylate monophosphate (c-di-GMP) regulates a series of cellular functions, including biofilm formation, motility, virulence, and other processes.
Jiahui He (5696630), Jieli Sun (5696636), Fang Wang (105926), Wenjuan Yan (561252), Wenhao Ruan (5696633)   +4 more
core   +1 more source