Results 101 to 110 of about 31,009,639 (254)
Advanced Science, EarlyView.Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li +6 more
wiley +1 more source
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
Frontiers in Cellular and Infection Microbiology, 2014 In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B.
Elizabeth A. Novak +2 more
doaj +1 more source
New insights into Legionella pneumophila biofilm regulation by c-di-GMP signaling
, 2016 The waterborne pathogen Legionella pneumophila grows as a biofilm, freely or inside amoebae. Cyclic-di-GMP (c-di-GMP), a bacterial second messenger frequently implicated in biofilm formation, is synthesized and degraded by diguanylate cyclases (DGCs) and
Christine Roques (472867) +5 more
core +1 more source
Advanced Science, EarlyView.MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge +13 more
wiley +1 more source
Arg656 in the CA domain of RavS is a key residue for c-di-GMP binding.
, 2019 (a, b) c-di-GMP binds to the DHp-CA domain of RavS. PAS-A, PAS-B and DHp-CA in (a), and DHp and CA domains of RavS in (b), were purified and the interaction with c-di-GMP was measured by MST. Each assay was repeated three times.
Shou-Ting Cheng (7225043) +2 more
core +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Roles of divalent metals in the regulation of cyclic di-GMP signaling in bacteria
Journal of BacteriologyMetals are essential co-factors that are important for the activity of many enzymes and, hence, bacterial life itself. Cyclic di-GMP (c-di-GMP) is an important signaling molecule that is prevalent across various bacterial phyla and involved in myriad ...
Aathmaja Anandhi Rangarajan +1 more
doaj +1 more source
Advanced Science, EarlyView.An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu +10 more
wiley +1 more source
The First FRET-Based RNA Aptamer NanoKit for Sensitively and Specifically Detecting c‑di-GMP
An effective method to identify c-di-GMP may significantly facilitate the exploration of its signaling pathways and bacterial pathogenesis. Herein, we have developed the first conjugated polymer-amplified RNA aptamer NanoKit with a unique core–shell ...
Xinghai Ning (1372887) +8 more
core +1 more source
Advanced Science, EarlyView.HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan +7 more
wiley +1 more source