Results 91 to 100 of about 31,009,639 (254)
mBio, 2019 Vibrio cholerae biofilm formation and associated motility suppression are correlated with increased concentrations of cyclic diguanylate monophosphate (c-di-GMP), which are in turn driven by increased levels and/or activity of diguanylate cyclases (DGCs).
David Zamorano-Sánchez +7 more
doaj +1 more source
Advanced Science, EarlyView.In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian +13 more
wiley +1 more source
Advanced Science, EarlyView.Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan +16 more
wiley +1 more source
, 2014 c-di-GMP是細菌中一個重要的訊息傳遞分子，參與調控細胞中許多重要的生物功能，包括毒性因子的表達、生物膜的合成以及細胞的運動…等，而其濃度則由GGDEF 和EAL domain負責調節；GGDEF domain具有 Diguanylate Cyclases (DGC) 活性以合成c-di-GMP，而EAL domain 則具有 Phosphodiesterases (PDE)活性以分解c-di-GMP。在先前的文獻中，已得知當細菌中c-di-GMP濃度高時，非典型第二型PilZ ...
廖怡婷, Liao, Yi-Ting
core +1 more source
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
Advanced Science, EarlyView.FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu +14 more
wiley +1 more source
Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs
Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley +1 more source
Advanced Science, EarlyView.This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang +10 more
wiley +1 more source
Analysis of the c-di-GMP mediated cell fate determination in Caulobacter crescentus [PDF]
, 2009 Cyclic-di-GMP (c-di-GMP) is a ubiquitous second messenger in bacteria, which has been recognized as a key regulator, antagonistically controlling the transition between motile, planktonic cells and surface attached, multicellular communities.
Abel, Sören
core +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Specific binding of validated ORFs to c-di-GMP.
, 2015 1 Binding and enzymatic activity is deemed positive if activity has been demonstrated for the purified protein or if mutation of residues required for c-di-GMP binding or enyzmatic activity regulate a c-di-GMP dependent phenotype.(+) = c-di-GMP binding ...
Kevin G. Roelofs (818861) +8 more
core +1 more source