Results 111 to 120 of about 24,065 (296)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

A mechanistic explanation linking adaptive mutation, niche change, and fitness advantage for the Wrinkly Spreader [PDF]

, 2014
Experimental evolution studies have investigated adaptive radiation in static liquid microcosms using the environmental bacterium Pseudomonas fluorescens SBW25.
Spiers, Andrew J.
core   +5 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Extraction and Quantification of Cyclic Di-GMP from Pseudomonas aeruginosa

Bio-Protocol, 2013
Cyclic di-GMP (c-di-GMP) has emerged as an important intracellular signaling molecule, controlling the transitions between planktonic (free-living) and sessile lifestyles, biofilm formation, and virulence in a wide variety of microorganisms.
Ankita Roy, Olga Petrova, Karin Sauer
doaj   +1 more source

High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]

, 2016
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon, Barahona, Baraquet, Berendsen, Boller, Burdette, Cao, Chinchilla, Clarke, Dangl, Dasgupta, Dong, Engl, Felix, Forsyth, Gal, Gomez-Gomez, Goymer, Guttman, Hann, Heese, Hengge, Hickman, Hickman, Jackson, Kazmierczak, Kovach, Kulasakara, Kunze, Lacombe, Lee, Li, Loon, Loper, Loper, Lugtenberg, Macho, Malone, Marino, Matilla, Miya, Newell, Nuhse, Peart, Pel, Perez-Mendoza, Plotnikova, Robleto, Rossez, Roux, Schulze, Schwessinger, Segonzac, Spangler, Starkey, Sun, Torres, Van Wees, Wang, Willmann, Winsor, Xin, Yan, Zamioudis, Zeng, Zhang, Zipfel, Zipfel, Zipfel   +68 more
core   +1 more source

Nature‐Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes

Advanced Science, EarlyView.
The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang, Qiyang Ding, Lei Shi, Ji Xia, Shuyue Zhang, Chenxin Jian, Yixiao Yan, Xiuhua Luo, Jiarui Wang, Ming Cheng, Yiqiong Jia, Hao Tian, Wei Gao   +12 more
wiley   +1 more source

Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti [PDF]

, 2015
An artificial increase of cyclic diguanylate (c-di-GMP) levels in Sinorhizobium meliloti 8530, a bacterium that does not carry known cellulose synthesis genes, leads to overproduction of a substance that binds the dyes Congo red and calcofluor.
Araujo Farias, Gabriela de, Lloret, Javier, Pérez-Mendoza, Daniel, Rodríguez Carvajal, Miguel Ángel, Romero-Jiménez, Lorena, Sanjuan, Juan, Trinidad Gallegos, Maria   +6 more
core   +1 more source

Nitric oxide controls c-di-GMP turnover in Dinoroseobacter shibae

Microbiology, 2018
The ubiquitous bacterial second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is involved in the regulation of numerous processes including biofilm formation, motility, virulence, cell cycle and differentiation. In this study, we searched the genome of the ecologically important marine alphaproteobacterium Dinoroseobacter shibae DFL12T for genes ...
Patricia, Bedrunka, Fabien, Olbrisch, Martina, Rüger, Susanne, Zehner, Nicole, Frankenberg-Dinkel   +4 more
openaire   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source