Results 131 to 140 of about 31,009,639 (254)

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

c-di-GMP level is important for development.

, 2016
(A) c-di-GMP levels in cells expressing the indicated proteins during starvation in suspension. The c-di-GMP levels are shown as mean ± SD from three biological replicates relative to WT at 0 hrs. * p Fig 1.
Volkhard Kaever (152216), Gregory T. Smaldone (2805442), Jennifer Liang (2288335), Jacob G. Malone (158210), Tobias Petters (2805439), Mitchell Singer (2805448), Lotte Søgaard-Andersen (135925), Eleftheria Trampari (2158030), Dorota Skotnicka (2805445)   +8 more
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa

Nature Communications
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis.
Xueliang Zhan, Kuo Zhang, Chenchen Wang, Qiao Fan, Xiujia Tang, Xi Zhang, Ke Wang, Yang Fu, Haihua Liang   +8 more
doaj   +1 more source

Quantifying c-di-GMP: A Call for Integration of Biological and Chemical Approaches

Applied Microbiology
Bacteria sense, respond, and adapt to rapidly changing environments through highly sensitive intracellular networks. Among them, cyclic-di-GMP (c-di-GMP) is a well-characterized second messenger controlling the transition from planktonic to sessile ...
Antoine Augias, Charlotte Nirma, Karine Vallée, Sophie Rodrigues, Yvann Bourigault   +4 more
doaj   +1 more source

Bacterial c-di-GMP is an immunostimulatory molecule.

, 2007
Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a mouse model.
Karaolis, David K R, Malouin, François, Muraille, Eric, Yang, De, Yoshimura, Teizo, Takahashi, Munehisa, Means, Terry K, Talbot, Brian G, Brouillette, Eric, Schroeder, John T, Hyodo, Mamoru, Philpott, Dana J, Hayakawa, Yoshihiro   +12 more
core  

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

c-di-GMP-based molecules as potent diguanylate cyclase (DGC) inhibitors

, 2015
The emergence of antibiotic and multi-target resistant bacterial strains is a major life-treating health problem with high socio-economic costs in developed countries.
Messina, Marco, SCORTICHINI, MIRKO, Rampioni, Giordano, Giardina, Giorgio, Cutruzzolà, Francesca, Fernicola, Silvia, CAPPELLACCI, Loredana, Paiardini, Alessandro, PETRELLI, Riccardo, Rinaldo, Serena, Leoni, Livia, TORQUATI, ILARIA   +11 more
core   +1 more source

Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria

Nature Communications
Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the ...
Xiaocui Ling, Xiao Liu, Kun Wang, Minhao Guo, Yanzhe Ou, Danting Li, Yulin Xiang, Jiachen Zheng, Lihua Hu, Hongyun Zhang, Weihui Li   +10 more
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source