Results 81 to 90 of about 24,065 (296)

Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators [PDF]

, 2017
The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway
Abel, Abel, Aldridge, Aldridge, Altschul, Attmannspacher, Baker, Belas, Berg, Boehm, Bond, Bourret, Bren, Briegel, Burkart, Chen, Chevance, Cho, Chou, Christen, Christen, Christen, Crooks, Davis, Deshpande, Dufour, Ely, Ely, Fang, Ferré, Finn, Galperin, Gao, Girgis, Habazettl, Harshey, Harshey, Hazelbauer, Hoffman, Hug, Jenal, Jenal, Jones, Karimova, Kawagishi, Kojima, Koyasu, Krell, Kulasekara, Lasker, Laventie, Lee, Li, Liu, Lori, Misselwitz, Molaei, Mukherjee, Nesper, Nierman, Parkinson, Paul, Persat, Pilizota, Porter, Porter, Porter, Russell, Sarkar, Scharf, Schneider, Schrader, Segata, Skerker, Sklenár, Smith, Sonnhammer, Sourjik, Steiner, Tindall, UniProt Consortium, Vacic, Volkman, Wang, Welch, Wolfe, Xie, Xu, Zhou, Zhou   +89 more
core   +1 more source

Identification of Ligand Analogues that Control c-di-GMP Riboswitches [PDF]

ACS Chemical Biology, 2012
Riboswitches for the bacterial second messenger c-di-GMP control the expression of genes involved in numerous cellular processes such as virulence, competence, biofilm formation, and flagella synthesis. Therefore, the two known c-di-GMP riboswitch classes represent promising targets for developing novel modulators of bacterial physiology.
Kazuhiro, Furukawa, Hongzhou, Gu, Narasimhan, Sudarsan, Yoshihiro, Hayakawa, Mamoru, Hyodo, Ronald R, Breaker   +5 more
openaire   +2 more sources

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Elevated intracellular cyclic‐di‐GMP level in Shewanella oneidensis increases expression of c‐type cytochromes

Microbial Biotechnology, 2020
Summary Electrochemically active biofilms are capable of exchanging electrons with solid electron acceptors and have many energy and environmental applications such as bioelectricity generation and environmental remediation.
Chun Kiat Ng, Jiabao Xu, Zhao Cai, Liang Yang, Ian P. Thompson, Wei E. Huang, Bin Cao   +6 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria

, 2016
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers.
Filloux, A, Valentini, M
core   +2 more sources

Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]

, 2015
The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel, Aldridge, Amikam, Aragón, Barahona, Baraquet, Bell, Benach, Bingle, Boehm, Boyd, Brencic, Christen, Clare E.M. Stevenson, Compant, Cuppels, David M. Lawson, De, Duerig, Eleftheria Trampari, Emsley, Engl, Fazli, Gal, Galibert, Gledhill, Haas, Hengge, Hickman, Ho, Hughes, Iino, Imada, Jacob G. Malone, Jonas, Kelley, Krasteva, Krissinel, Kuchma, Kuchma, Kulasakara, Lee, Lindeberg, Little, Lovering, Lucchini, Lugtenberg, Macnab, Macnab, Martínez-Granero, Matilla, McNicholas, Miller, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Minamino, Moscoso, Moscoso, Naseby, Navazo, Nesper, Newell, Newell, Pfeilmeier, Pultz, Pérez-Mendoza, Qi, Rainey, Richard H. Little, Roelofs, Ryan, Schirmer, Solano, Srivastava, Starkey, Steiner, Story, Sudarsan, Tchigvintsev, Thomas Wilhelm, Tschowri, Wassmann, Wilhelm, Woodcock, Xin   +89 more
core   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa

, 2014
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen and a threat for immune-compromised and Cystic Fibrosis patients. It is responsible for acute and chronic infections and can switch between these lifestyles upon taking an informed ...
Filloux, A, Hui, K, Jaeger, T, Jenal, U, Moscoso, JA, Valentini, M   +5 more
core   +2 more sources

Small secreted proteins enable biofilm development in the cyanobacterium Synechococcus elongatus. [PDF]

, 2016
Small proteins characterized by a double-glycine (GG) secretion motif, typical of secreted bacterial antibiotics, are encoded by the genomes of diverse cyanobacteria, but their functions have not been investigated to date.
Golden, Susan, Nagar, Elad, Parnasa, Rami, Reich, Ziv, Schwarz, Rakefet, Sendersky, Eleonora, Simkovsky, Ryan   +6 more
core   +1 more source