Results 161 to 170 of about 470,032 (357)

Label‐Free FET Based Biosensor for Detection of Engineered CAR T‐Cells at Single Cell Resolution

Advanced Sensor Research, EarlyView.
A silicon nanowire field‐effect transistor (SiNW FET) biosensor that allows for label‐free, real‐time detection and quantification of engineered Chimeric Antigen Receptor (CAR) T‐cells at single‐cell resolution is presented. By mimicking the CAR‐specific antigen interface, the platform provides highly selective analysis of individual cell surface ...
Trang Anh Nguyen‐Le, Isli Cela, Anja Feldmann, Chang‐Ki Baek, Michael Bachmann, Larysa Baraban   +5 more
wiley   +1 more source

Cyclic DI-GMP Phosphodiesterases RmdA and RmdB are involved in regulating colony morphology and development in Streptomyces coelicolor. Journal of Bacteriology [PDF]

, 2012
Cyclic dimeric GMP (c-di-GMP) regulates numerous processes in Gram-negative bacteria, yet little is known about its role in Gram-positive bacteria.
Bennett, Jennifer A., Gelger, Robert M., Gomelsky, Mark, Hull, Travis D, Johnson, Ryan C., Klena, Nikola T., Ryu, Min-Hyung, Sullivan, Matthew J   +7 more
core   +2 more sources

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Regulation by cyclic di-GMP in Myxococcus xanthus [PDF]

, 2016
The nucleotide-based second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) is involved in regulating a plethora of processes in bacteria that are typically associated with lifestyle changes.
Skotnicka, Dorota
core   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

mBio, 2010
The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between motile and sessile growth in a wide range of bacteria. Understanding how microbes control c-di-GMP metabolism to activate specific pathways is complicated by the ...
Judith H. Merritt, Dae-Gon Ha, Kimberly N. Cowles, Wenyun Lu, Diana K. Morales, Joshua Rabinowitz, Zemer Gitai, George A. O’Toole   +7 more
doaj   +1 more source

Understanding aspects of alginate biosynthesis and regulation by Pseudomonas aeruginosa : a thesis presented in partial fulfilment of the requirements of the degree of Doctor of Philosophy in Microbiology at Massey University, Palmerston North, New Zealand [PDF]

, 2017
Alginate is a medically and industrially important polymer produced by seaweeds and certain bacteria. The bacterium Pseudomonas aeruginosa over-produces alginate during cystic fibrosis lung infections, forming biofilms, making the infection difficult to ...
Wang, Yajie
core  

Denitrification-derived nitric oxide modulates biofilm formation in Azospirillum brasilense [PDF]

, 2013
Azospirillum brasilense is a rhizobacterium that provides beneficial effects on plants when they colonize roots. The formation of complex bacterial communities known as biofilms begins with the interaction of planktonic cells with surfaces in response to
Arruebarrena Di Palma, Andrés, Baca, Beatriz E., Creus, Cecilia Mónica, Lamattina, Lamattina, Moreno Ramírez, Lizbeth, Pereyra, Cintia Mariana, Pereyra, María Alejandra, Xiqui Vazquez, Maria L.   +7 more
core   +1 more source

Enhancing the Effectiveness of Chemotherapy in Osteosarcoma by Targeting Tumour‐Associated Macrophages (TAMs) through STING Activation

Advanced Therapeutics, EarlyView.
Osteosarcoma isa highly aggressive bone cancer with an immunosuppressive tumor microenvironment that limits immunotherapy. This study explores STING pathway activation to reprogram tumor‐associated macrophages into a tumoricidal M1‐like phenotype and enhance doxorubicin efficacy. Results show that doxorubicin alone failed to activate the STING pathway,
Jordan C. O'Donoghue, Amanda Guitián‐Caamaño, Maeve Boyce, Fiona E. Freeman   +3 more
wiley   +1 more source

Enzymatically Active and Inactive Phosphodiesterases and Diguanylate Cyclases Are Involved in Regulation of Motility or Sessility in Escherichia coli CFT073

mBio, 2012
Intracellular concentration of cyclic diguanylate monophosphate (c-di-GMP), a second messenger molecule, is regulated in bacteria by diguanylate cyclases (DGCs) (synthesizing c-di-GMP) and phosphodiesterases (PDEs) (degrading c-di-GMP).
Rachel R. Spurbeck, Rebecca J. Tarrien, Harry L. T. Mobley   +2 more
doaj   +1 more source