Results 21 to 30 of about 17,188 (276)

The global regulation of c-di-GMP and cAMP in bacteria. [PDF]

mLife
AbstractNucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria. The best‐studied examples are cyclic AMP (cAMP) and bis‐(3′–5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP), which both act as global regulators.
Liu C, Shi R, Jensen MS, Zhu J, Liu J, Liu X, Sun D, Liu W.   +7 more
europepmc   +4 more sources

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems. [PDF]

PLoS Pathogens, 2015
Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a variety of complex processes through a diverse set of c-di-GMP receptor proteins.
Kevin G Roelofs, Christopher J Jones, Sarah R Helman, Xiaoran Shang, Mona W Orr, Jonathan R Goodson, Michael Y Galperin, Fitnat H Yildiz, Vincent T Lee   +8 more
doaj   +1 more source

Quorum-Sensing Master Regulator VfmE Is a c-di-GMP Effector That Controls Pectate Lyase Production in the Phytopathogen Dickeya dadantii

Microbiology Spectrum, 2022
Dickeya dadantii is a phytopathogenic bacterium that causes diseases on a wide range of host plants. The pathogen secretes pectate lyases (Pel) through the type II secretion system (T2SS) that degrades the cell wall in host plants.
Biswarup Banerjee, Quan Zeng, Manda Yu, Brian Y. Hsueh, Christopher M. Waters, Ching-Hong Yang   +5 more
doaj   +1 more source

High Levels of Cyclic Diguanylate Interfere with Beneficial Bacterial Colonization

mBio, 2022
During colonization of the Hawaiian bobtail squid (Euprymna scolopes), Vibrio fischeri bacteria undergo a lifestyle transition from a planktonic motile state in the environment to a biofilm state in host mucus.
Ruth Y. Isenberg, David G. Christensen, Karen L. Visick, Mark J. Mandel   +3 more
doaj   +1 more source

Bacterial c-di-GMP Is an Immunostimulatory Molecule [PDF]

The Journal of Immunology, 2007
Abstract Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a mouse model. We now report that c-di-GMP is an immodulator and immunostimulatory molecule.
Karaolis, David K R, Means, Terry K, Yang, De, Takahashi, Munehisa, Yoshimura, Teizo, Muraille, Eric, Philpott, Dana J, Schroeder, John T, Hyodo, Mamoru, Hayakawa, Yoshihiro, Talbot, Brian G, Brouillette, Eric, Malouin, François   +12 more
openaire   +3 more sources

Identification of Cyclic-di-GMP-Modulating Protein Residues by Bidirectionally Evolving a Social Behavior in Pseudomonas fluorescens

mSystems, 2022
Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
doaj   +1 more source

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Scientific Reports, 2023
Bacterial second messengers c-di-GMP and (p)ppGpp have broad functional repertoires ranging from growth and cell cycle control to the regulation of biofilm formation and virulence.
Badri Nath Dubey, Viktoriya Shyp, Geoffrey Fucile, Holger Sondermann, Urs Jenal, Tilman Schirmer   +5 more
doaj   +1 more source

Protein Deacetylase CobB Interplays with c-di-GMP [PDF]

SSRN Electronic Journal, 2018
AbstractAs a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes such as bacterial motility and transcription regulation. CobB is the Sir2 family protein deacetylase that controls energy metabolism, chemotaxis and DNA supercoiling in many bacteria. Using anE.coliproteome microarray, we found that c-di-GMP strongly
Xu, Zhaowei, Zhang, Hainan, Zhang, Xingrun, Liu, Chengxi, Jiang, Hewei, Wu, Fanlin, Qian, Lili, Czajkowsky, Daniel M., Guo, Shujuan, Bi, Lijun, Wang, Shihua, Li, Haitao, Tan, Minjia, Feng, Lei, Hou, Jingli, Tao, Sheng-ce   +15 more
openaire   +3 more sources

Dissecting the molecular dance: c-di-GMP, cAMP-CRP, and VfmH collaboration in pectate lyase regulation for Dickeya dadantii—unveiling the soft rot pathogen’s strategy

Microbiology Spectrum, 2023
Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee, Xiaochen Yuan, Ching-Hong Yang   +2 more
doaj   +1 more source

A Filter Binding Assay to Quantify the Association of Cyclic di-GMP to Proteins

Bio-Protocol, 2015
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many processes in bacteria including biofilm formation, motility, and virulence (Hengge, 2009). Analysis of c-di-GMP binding properties of bacterial proteins is an important step to
Disha Srivastava, Christopher Waters
doaj   +1 more source