Results 21 to 30 of about 24,734 (337)

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems. [PDF]

PLoS Pathogens, 2015
Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a variety of complex processes through a diverse set of c-di-GMP receptor proteins.
Kevin G Roelofs, Christopher J Jones, Sarah R Helman, Xiaoran Shang, Mona W Orr, Jonathan R Goodson, Michael Y Galperin, Fitnat H Yildiz, Vincent T Lee   +8 more
doaj   +1 more source

High Levels of Cyclic Diguanylate Interfere with Beneficial Bacterial Colonization

mBio, 2022
During colonization of the Hawaiian bobtail squid (Euprymna scolopes), Vibrio fischeri bacteria undergo a lifestyle transition from a planktonic motile state in the environment to a biofilm state in host mucus.
Ruth Y. Isenberg, David G. Christensen, Karen L. Visick, Mark J. Mandel   +3 more
doaj   +1 more source

Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation [PDF]

PLOS Genetics, 2020
The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle. Motility and biofilm formation are inversely regulated by the second messenger molecule cyclic dimeric guanosine monophosphate (c-di-GMP).
Daniel C. Wu, David Zamorano-Sánchez, Fernando A. Pagliai, Jin Hwan Park, Kyle A. Floyd, Calvin K. Lee, Giordan Kitts, Christopher B. Rose, Eric M. Bilotta, Gerard C. L. Wong, Fitnat H. Yildiz   +10 more
openaire   +5 more sources

Quorum-Sensing Master Regulator VfmE Is a c-di-GMP Effector That Controls Pectate Lyase Production in the Phytopathogen Dickeya dadantii

Microbiology Spectrum, 2022
Dickeya dadantii is a phytopathogenic bacterium that causes diseases on a wide range of host plants. The pathogen secretes pectate lyases (Pel) through the type II secretion system (T2SS) that degrades the cell wall in host plants.
Biswarup Banerjee, Quan Zeng, Manda Yu, Brian Y. Hsueh, Christopher M. Waters, Ching-Hong Yang   +5 more
doaj   +1 more source

Polymorphism of the Signaling Molecule c-di-GMP [PDF]

Journal of the American Chemical Society, 2006
Using UV, CD, and NMR, we demonstrate that the important bacterial signaling molecule involved in biofilm formation, cyclic diguanosine monophosphate (c-di-GMP), exists as a mixture of five different but related structures in an equilibrium that is sensitive both to its concentration and to the metal present. At the lower concentrations used for UV and
Zhaoying, Zhang, Seho, Kim, Barbara L, Gaffney, Roger A, Jones   +3 more
openaire   +2 more sources

Bacterial c-di-GMP Is an Immunostimulatory Molecule [PDF]

The Journal of Immunology, 2007
Abstract Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a mouse model. We now report that c-di-GMP is an immodulator and immunostimulatory molecule.
Karaolis, David K R, Means, Terry K, Yang, De, Takahashi, Munehisa, Yoshimura, Teizo, Muraille, Eric, Philpott, Dana J, Schroeder, John T, Hyodo, Mamoru, Hayakawa, Yoshihiro, Talbot, Brian G, Brouillette, Eric, Malouin, François   +12 more
openaire   +2 more sources

Protein Deacetylase CobB Interplays with c-di-GMP [PDF]

SSRN Electronic Journal, 2018
AbstractAs a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes such as bacterial motility and transcription regulation. CobB is the Sir2 family protein deacetylase that controls energy metabolism, chemotaxis and DNA supercoiling in many bacteria. Using anE.coliproteome microarray, we found that c-di-GMP strongly
Xu, Zhaowei, Zhang, Hainan, Zhang, Xingrun, Liu, Chengxi, Jiang, Hewei, Wu, Fanlin, Qian, Lili, Czajkowsky, Daniel M., Guo, Shujuan, Bi, Lijun, Wang, Shihua, Li, Haitao, Tan, Minjia, Feng, Lei, Hou, Jingli, Tao, Sheng-ce   +15 more
openaire   +1 more source

Identification of Cyclic-di-GMP-Modulating Protein Residues by Bidirectionally Evolving a Social Behavior in Pseudomonas fluorescens

mSystems, 2022
Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
doaj   +1 more source

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Scientific Reports, 2023
Bacterial second messengers c-di-GMP and (p)ppGpp have broad functional repertoires ranging from growth and cell cycle control to the regulation of biofilm formation and virulence.
Badri Nath Dubey, Viktoriya Shyp, Geoffrey Fucile, Holger Sondermann, Urs Jenal, Tilman Schirmer   +5 more
doaj   +1 more source

Polarity of c-di-GMP synthesis and degradation

microLife, 2023
AbstractThe bacterial cell pole has long been recognized as a defined compartment for enzymatic activities that are important or even vital for the cell. Polarity of diguanylate cyclases and phosphodiesterases, enzymes that synthesize and degrade the second messenger c-di-GMP, has now been demonstrated for several bacterial systems.
Vanessa Kreiling, Kai M Thormann
openaire   +2 more sources