Results 21 to 30 of about 459,122 (273)
Local signaling enhances output specificity of bacterial c-di-GMP signaling networks
microLife, 2023 For many years the surprising multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins has intrigued researchers studying bacterial second messengers.
Eike H. Junkermeier, R. Hengge
semanticscholar +1 more source
Bacterial c-di-GMP Is an Immunostimulatory Molecule [PDF]
The Journal of Immunology, 2007 Abstract Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a mouse model. We now report that c-di-GMP is an immodulator and immunostimulatory molecule.
Karaolis, David K R +12 more
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Nucleic Acids Research, 2023 Actinobacteria are ubiquitous bacteria undergoing complex developmental transitions coinciding with antibiotic production in response to stress or nutrient starvation. This transition is mainly controlled by the interaction between the second messenger c-
Yu V. Fu +5 more
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Scientific Reports, 2021 Clostridioides difficile is the leading cause of nosocomial antibiotic-associated diarrhoea worldwide, yet there is little insight into intestinal tract colonisation and relapse.
Lisa F. Dawson +7 more
semanticscholar +1 more source
npj Biofilms and Microbiomes, 2021 Microbial biofilms are involved in a number of infections that cannot be cured, as microbes in biofilms resist host immune defenses and antibiotic therapies.
J. B. Andersen +13 more
semanticscholar +1 more source
The role of RNA regulators, quorum sensing and c‐di‐GMP in bacterial biofilm formation
FEBS Open Bio, 2022 Biofilms provide an ecological advantage against many environmental stressors, such as pH and temperature, making it the most common life‐cycle stage for many bacteria.
Manuel Condinho +5 more
semanticscholar +1 more source
Protein Deacetylase CobB Interplays with c-di-GMP [PDF]
SSRN Electronic Journal, 2018 AbstractAs a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes such as bacterial motility and transcription regulation. CobB is the Sir2 family protein deacetylase that controls energy metabolism, chemotaxis and DNA supercoiling in many bacteria. Using anE.coliproteome microarray, we found that c-di-GMP strongly
Xu, Zhaowei +15 more
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Transcription of the Alginate Operon in Pseudomonas aeruginosa Is Regulated by c-di-GMP
Microbiology spectrum, 2022 The proliferation of alginate-overproducing P. aeruginosa variants in the lungs of cystic fibrosis patients often leads to chronic infection. The alginate functions as a biofilm matrix that protects the bacteria against host immune defenses and ...
Ziwei Liang +7 more
semanticscholar +1 more source
Thiophosphate Analogs of c-di-GMP: Impact on Polymorphism [PDF]
Nucleosides, Nucleotides & Nucleic Acids, 2009 Seven phosphorothioate analogs of c-di-GMP (all diastereomers of mono-, di-, and trithiophosphates) were prepared to assess the impact of the thioate substitutions on c-di-GMP polymorphism using 1D (1)H and (31)P NMR, along with 2D NOESY and DOSY, for both the Na(+) and K(+) salts.
Barbara L. Gaffney +4 more
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Nano Reseach, 2022 The activation of the stimulating factor of the interferon gene (STING) pathway can enhance the immune response within the tumor. Cyclic diguanylate monophosphate (c-di-GMP) is a negatively charged, hydrophilic STING agonist, however, its effectiveness ...
Ziyuan Zhang +7 more
semanticscholar +1 more source