Results 31 to 40 of about 17,188 (276)

Thiophosphate Analogs of c-di-GMP: Impact on Polymorphism [PDF]

Nucleosides, Nucleotides & Nucleic Acids, 2009
Seven phosphorothioate analogs of c-di-GMP (all diastereomers of mono-, di-, and trithiophosphates) were prepared to assess the impact of the thioate substitutions on c-di-GMP polymorphism using 1D (1)H and (31)P NMR, along with 2D NOESY and DOSY, for both the Na(+) and K(+) salts.
Barbara L. Gaffney, Seho Kim, Roger A. Jones, Elizabeth Veliath, Jianwei Zhao   +4 more
openaire   +3 more sources

Systematic Analysis of c-di-GMP Signaling Mechanisms and Biological Functions in Dickeya zeae EC1

mBio, 2020
Dickeya zeae is an important and aggressive bacterial phytopathogen that can cause substantial economic losses in banana and rice plantations. We previously showed that c-di-GMP signaling proteins (cyclases/phosphodiesterases) in D.
Yufan Chen, Jianuan Zhou, Mingfa Lv, Zhibin Liang, Matthew R. Parsek, Lian-hui Zhang   +5 more
doaj   +1 more source

Dual Regulatory Role Exerted by Cyclic Dimeric GMP To Control FsnR-Mediated Bacterial Swimming

mBio, 2022
Bacterial motility has great medical and ecological significance because of its essential role in bacterial survival and pathogenesis. Cyclic dimeric GMP (c-di-GMP), a second messenger in bacteria, is the predominant regulator of flagellar synthesis and ...
Xin Zhang, Yan Wang, Yao Wu, Zhi-Hui Yuan, Zhen Cai, Wei Qian, Xin Ge, Fang-Fang Wang   +7 more
doaj   +1 more source

C-di-GMP Pathway in Biomining Bacteria

Advanced Materials Research, 2009
Acidithiobacillus ferrooxidans, A. thiooxidans, and A. caldus are acidophilic Gram-negative -proteobacteria involved in the bioleaching of metal sulfides. Bacterial attachment to mineral surface and biofilm development play a pivotal role in this process.
Castro, M., Ruiz, L. M., Barriga, A., Jerez, C. A., Holmes, D., Guiliani, N.   +5 more
openaire   +6 more sources

Cyclic Diguanylate Regulates Virulence Factor Genes via Multiple Riboswitches in Clostridium difficile

mSphere, 2018
The intracellular signaling molecule cyclic diguanylate (c-di-GMP) regulates many processes in bacteria, with a central role in controlling the switch between motile and nonmotile lifestyles.
Robert W. McKee, Carissa K. Harvest, Rita Tamayo   +2 more
doaj   +1 more source

Single Molecule Studies of the c-di-GMP Riboswitch [PDF]

Biophysical Journal, 2011
Cyclic diguanylate (c-di-GMP) is a second messenger signaling molecule important for the regulation of many bacterial processes, including virulence, motility, and biofilm formation. Recent developments have shown that c-di-GMP is recognized by a riboswitch, an mRNA domain that controls gene expression in response to varying concentrations of a target ...
Sharla Wood, Adrian R. Ferré-D'Amaré, Adrian R. Ferré-D'Amaré, David Rueda, Nadia Kulshina   +4 more
openaire   +2 more sources

Evolution of a σ–(c-di-GMP)–anti-σ switch [PDF]

Proceedings of the National Academy of Sciences, 2021
SignificanceDiverse bacterial lifestyle transitions are controlled by the nucleotide second messenger c-di-GMP, including virulence, motility, and biofilm formation. To control such fundamentally distinct processes, the set of genes under c-di-GMP control must have gone through several shifts during bacterial evolution.
Maria A. Schumacher, Kelley A. Gallagher, Neil A. Holmes, Govind Chandra, Max Henderson, David T. Kysela, Richard G. Brennan, Mark J. Buttner   +7 more
openaire   +3 more sources

Impact of c-di-GMP on the Extracellular Proteome of Rhizobium etli

Biology, 2022
Extracellular matrix components of bacterial biofilms include biopolymers such as polysaccharides, nucleic acids and proteins. Similar to polysaccharides, the secretion of adhesins and other matrix proteins can be regulated by the second messenger cyclic diguanylate (cdG). We have performed quantitative proteomics to determine the extracellular protein
María J. Lorite, Ariana Casas-Román, Lourdes Girard, Sergio Encarnación, Natalia Díaz-Garrido, Josefa Badía, Laura Baldomá, Daniel Pérez-Mendoza, Juan Sanjuán   +8 more
openaire   +5 more sources

Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2017
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm formation via the reduction of motility and production of biofilm ...
Song Lin Chua, Yang Liu, Yingying Li, Hui Jun Ting, Gurjeet S. Kohli, Zhao Cai, Pipob Suwanchaikasem, Kelvin Kau Kit Goh, Sean Pin Ng, Tim Tolker-Nielsen, Liang Yang, Liang Yang, Michael Givskov, Michael Givskov   +13 more
doaj   +1 more source

Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation [PDF]

PLOS Genetics, 2020
The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle. Motility and biofilm formation are inversely regulated by the second messenger molecule cyclic dimeric guanosine monophosphate (c-di-GMP).
Daniel C. Wu, David Zamorano-Sánchez, Fernando A. Pagliai, Jin Hwan Park, Kyle A. Floyd, Calvin K. Lee, Giordan Kitts, Christopher B. Rose, Eric M. Bilotta, Gerard C. L. Wong, Fitnat H. Yildiz   +10 more
openaire   +6 more sources