Results 111 to 120 of about 53,609 (266)

C/EBPbeta-2 confers EGF-independent growth and disrupts the normal acinar architecture of human mammary epithelial cells

Molecular Cancer, 2005
Background The transcription factor, C/EBPbeta, is a key regulator of growth and differentiation in the mammary gland. There are three different protein isoforms of C/EBPbeta. C/EBPbeta-1 and -2 are transactivators, and differ by only 23 N-terminal amino
Sealy Linda, Wells Sam, Bundy Linda
doaj   +1 more source

Anthrazykline und Herceptin® als neue Therapieoption beim metastasierten Mammakarzinom [PDF]

, 2000
Single-agent treatment with the humanized monoclonal antibody trastuzumab (herceptin) has shown remarkable activity in patients with metastatic breast cancer overexpressing the HER-2/neu proto-oncogen.
Crohns, C., Hepp, H., Kahlert, S., Untch, M.   +3 more
core   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Expression of epidermal growth factors and apoptosis markers in pancreatic ductal adenocarcinoma.

Folia Histochemica et Cytobiologica, 2010
<strong>BACKGROUND</strong><br />Epidermal growth factor family members: EGF, EGFR and the c-erbB-2(HER-2/neu) are involved in the growth of pancreatic ductal carcinoma, its invasiveness and metastases.
Jolanta Czyzewska, Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Andrzej Kemona   +3 more
doaj   +1 more source

C-erbB-2 mRNA in breast cancer specimens that exhibit membrane or cytoplasmic immunoreactivity for c-erbB-2.

Oncology research, 2000
Immunocytochemically detected membrane staining for c-erbB-2 in 20-30% of breast cancers correlates with a poorer prognosis for the patients. However, cytoplasmic immunoreactivity for c-erbB-2 has also been found in some specimens using some particular antisera, and it has been suggested that this staining arises from a protein located in the ...
S L, Taylor, P S, Rudland, R, Barraclough   +2 more
openaire   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Prognostic factors affecting disease-free survival rate following surgical resection of primary breast cancer

European Journal of Histochemistry, 2009
In order to identify the prognostic factors that significantly influence the disease-free survival rate after surgical resection of primary breast cancers, we determined tumour and lymph node grades, and immunohistochemical staining for estrogen and ...
K Horita, A Yamaguchi, K Hirose, M Ishida, S Noriki, Y Imamura, M Fukuda   +6 more
doaj   +1 more source

Immunohistochemical localization of c-erbB-2 in human breast carcinomas

Molecular and Cellular Probes, 1987
This study was carried out to assess the utility of antibodies raised to synthetic peptides of the predicted sequence of the c-erbB-2 gene product to identify immunocytochemically those tumours overexpressing this putative transmembrane receptor. Staining with rabbit antiserum 21N gave the best correlation with gene amplification and did not stain the ...
B A, Gusterson, W J, Gullick, D J, Venter, T J, Powles, C, Elliott, S, Ashley, A, Tidy, S, Harrison   +7 more
openaire   +2 more sources

PERBEDAAN SKOR HISTOLOGI C-erbB-2,PROLIFERASI ENDOTEL PEMBULUH DARAH : DENGAN DAN TANPA INFILTRASI LEVOBUPIVAKAIN PADA PENYEMBUHAN LUKA TIKUS WISTAR [PDF]

, 2006
Background : Postoperative acute pain stimulates clinical pathophysiologic symtoms, depress immune responses which leads to delayed wound healing process. Levobupivacaine is a long acting local anaesthetic, proven good for pain controll.
Trisari, Curniawati
core  

The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary [PDF]

, 1994
Fluorescencein situ hybridization (FISH) of microlibraries established from distinct chromosome subregions can test the evolutionary conservation of chromosome bands as well as chromosomal rearrangements that occurred during primate evolution and will ...
A Baldini, A Jauch, A. Jauch, B Dutrillaux, B. Horsthemke, C Lengauer, C Lengauer, C Lengauer, C. Lengauer, D Pinkel, G. Senger, H-J Lüdecke, H. -J. L�decke, J Wienberg, J Wienberg, J. Wienberg, JJ Yunis, JW Ijdo, LEM Boer de, M Djalali, M Klever, N. Arnold, P Lichter, R Avarello, R Stanyon, R Stanyon, RA Wells, T Cremer, T Ried, T. Cremer, U Trautmann, U. Claussen, Z Gelman-Kohan   +32 more
core   +1 more source