Results 91 to 100 of about 39,006,954 (221)

S100 Calcium‐Binding Protein 16 (S100A16) Promotes Hepatic Stellate Cell Activation Via Erb‐B2 Receptor Tyrosine Kinase 2 (ERBB2)‐mediated Glycolysis to Facilitate Liver Fibrosis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Hepatic stellate cell (HSC) activation is a key mediator in hepatic fibrosis, with glycolysis serving a key regulatory function. S100 calcium‐binding protein 16 (S100A16) has been associated with various pathologies; however, its function and underlying mechanisms in liver fibrosis remains elusive.
Shiyu Ou, Xiaoling Tang, Juan Liu, Rong Ouyang, Shijiang Huang, Shuwen Weng, Jinping Qin, Dingheng Liang, Ling Du, Zhongzhuan Li   +9 more
wiley   +1 more source

Expression of epidermal growth factors and apoptosis markers in pancreatic ductal adenocarcinoma.

Folia Histochemica et Cytobiologica, 2010
<strong>BACKGROUND</strong><br />Epidermal growth factor family members: EGF, EGFR and the c-erbB-2(HER-2/neu) are involved in the growth of pancreatic ductal carcinoma, its invasiveness and metastases.
Jolanta Czyzewska, Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Andrzej Kemona   +3 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

C－erbB－2表达对乳腺浸润性导管癌预后的预测

Zhongshan Daxue xuebao. Yixue kexue ban, 1996
应用单克隆抗体Ｃ－ｅｒｂＢ－２肿瘤蛋白及免疫组化（ＬＳＡＢ）法，对８４例乳腺浸润性导管癌作Ｃ－ｅｒｂＢ－２癌基因蛋白产物表达（简称Ｃ－ｅｒｂＢ－２表达）检测并与随诊资料进行比较分析，结果（１）Ｃ－ｅｒｂＢ－２在本组病例的表达率为５５．９％（４７／８４）。（２）Ｃ－ｅｒｂＢ－２表达与肿瘤的ＴＮＭ分期、复发／远必转移、５ａ生存率无相关性（Ｐ＞０．０５）、而仅与腋淋巴结转移状况和２ａ死亡率有关（Ｐ＜０．００５及Ｐ＜０．０５）。（３）有／无淋巴结转移病例的Ｃ－ｅｒｂＢ－２表达与患者的预后均无关（Ｐ＞０．７５ ...
doaj  

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent.

, 2004
c-erbB-2-positive breast carcinomas are highly aggressive tumors. In vitro data on breast cell lines showed that c-erbB-2 enhanced translational efficiency of hypoxia inducible factor-1alpha (HIF1alpha) production (Laughner et al., Mol Cell Biol 2001;21 ...
Simopoulos, C, Harris, AL, Koukourakis, MI, Polychronidis, A, Giatromanolaki, A, Gatter, KC, Sivridis, E   +6 more
core   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

上皮钙黏蛋白及C-erbB-2在非小细胞肺癌中的表达及意义

Zhongguo shiyan zhenduanxue, 2012
目的探讨上皮钙黏蛋白（E-cad、β-cat）和C-erbB-2在非小细胞肺癌（NSCLC）中的表达及其相互之间的关系。方法免疫组化SP法检测了41例非小细胞肺癌标本中E-cad、β-cat、C-erbB-2的表达情况。结果 E-cad及β-cat在NSCLC中低表达,并与临床分期、病理分级及淋巴结转移有明显相关性 ...
王凤玲, 隋小芳, 杨永清, 陈尚君   +3 more
doaj  

Discovery of Potent EGFR Inhibitors for Del19 and L858R/T790M Mutants Through Structure‐Based Virtual Screening and Biological Evaluation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
XJ2‐2 overcomes NSCLC by blocking EGFR‑driven AKT/ERK cascades. ABSTRACT Epidermal growth factor receptor (EGFR) mutation‐mediated drug resistance represents a major clinical challenge in the treatment of non‐small cell lung cancer (NSCLC). In this study, the lead compound XJ2‐2 was identified through structure‐based virtual screening.
Ting Xu, Yuchen Zhao, Mengfei Chen, Lijuan Zuo, Hanshuang Cai, Yuguo Liu, Chuanfeng Liu, Jing Shi   +7 more
wiley   +1 more source

Vascular endothelial growth factor, c-erbB-2 and c-erbB-3 expression in colorectal adenoma and adenocarcinoma

, 2005
Aim: To analyze vascular endothelial growth factor (VEGF), c-erbB-2 and c-erbB-3 expression and to evaluate their relation to clinicopathologic parameters and pathogenesis of colorectal carcinoma.
Ebinc, FA, Akyurek, X, Dursun, A, Unsal, D, Mentes, BB, Uner, A   +5 more
core   +1 more source