Results 101 to 110 of about 39,006,954 (221)

Prognostic and clinical implications of c-erbB-2 expression in patients with oral cancer: A meta-analysis. [PDF]

Medicine (Baltimore), 2020
Meng Y, Yang P, Ma L.
europepmc   +1 more source

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

, 1991
The erbB-2 gene product, gp185erbB-2, unlike the structurally related epidermal growth factor (EGF) receptor (EGFR), exhibits constitutive kinase and transforming activity.
O. Segatto, F. Fazioli, U. H. Kim, P. P. Di Fiore, C. J. Molloy, S. G. Rhee   +5 more
core   +2 more sources

erbB 基因表达与乳腺癌发生的相关关系

Zhongshan Daxue xuebao. Yixue kexue ban, 1998
目的: 研究 c -erbB-2, c-erbB-4 原癌基因过度表达与乳腺癌发生及其病理参数的相关关系。方法: 对 122 例乳腺疾病石蜡切块,其 中 80 例乳腺癌, 16 例乳腺纤维腺瘤, 9 例乳腺纤维囊性病, 17 例乳腺癌转移淋巴结均采用免疫组化( LSAB 法)结合计算机图象分析研究原癌 基因产物 c-erbB-2, c-erbB-4的表达情况。结果: c-erbB-2 在乳腺癌中存在过度表达, P
doaj  

p53、bcl-2和c-erbB-2在恶性卵巢上皮性肿瘤中的表达及临床意义

Zhongguo shiyan zhenduanxue, 2006
目的检测62例恶性卵巢上皮性肿瘤中p53、bcl-2和c-erbB-2的表达情况以探讨三种基因对恶性卵巢上皮性肿瘤的早期诊断及预后判断的意义。方法采用免疫组织化学方法检测p53b、cl-2 and c-erbB-2在恶性卵巢上皮性肿瘤中的表达及其与组织学分类,临床分期,腹水,淋巴结转移预后的关系。结果恶性卵巢上皮性肿瘤在p53、bcl-2 and c-erbB-2的表达阳性率分别52.23%,62.90%和45.16%与卵巢瘤组和正常组之间比较差异有显著性 ...
许天敏, 崔满华, 林杨, 何凯
doaj  

幽门螺杆菌感染与胃癌P⁵³、C-erbB-2表达的关系

Zhongguo shiyan zhenduanxue, 2002
目的　探讨幽门螺杆菌感染与胃癌P53 、C erbB - 2的关系。方法　应用Warthin -Starry染色法检测幽门螺杆菌 ,免疫酶组化SP法检测P53 、C -erbB - 2基因蛋白。结果　Hp感染率在胃癌和癌前病变组中均高于对照组 ,而前两组差异无显著性 ,Hp感染与C erbB 2过度表达有关。P53 仅在胃癌组织中表达 ,Hp感染者与P53 过度表达有关 （P
房学东, 杨作森, 冯涛
doaj  

c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma--an immunocytochemical study

, 1994
The type I growth factor receptor family has been found to play an important role in the control of normal growth and differentiation. Moreover, the epidermal growth factor receptor and the c-erbB-2 oncogene seem to be implicated in the pathogenesis and ...
S. Maluta, O. Caffo, P. Boracchi, P. Bevilacqua, W. J. Gullick, G. Gasparini, P. Dalla Palma, E. Leonardi, F. Pozza, N. R. Lemoine   +9 more
core   +1 more source

Protein expression of c-erbB-2 and p53 in normal ducts, ductal carcinoma in situ and invasive carcinoma of the same breast

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Breast cancer is thought to derive from progressively aberrant, non-invasive breast lesions, but it is not known exactly how invasive breast cancer develops from these lesions.
Marcus Vinicius Martins de Menezes, Anna Letícia Oliveira Cestari, Orlando Almeida, Marcelo Alvarenga, Glauce Aparecida Pinto, Maria Salete Costa Gurgel, Gustavo Antônio de Souza, Luiz Carlos Zeferino   +7 more
doaj   +1 more source

EPİTELYAL OVER TÜMÖRLERİ İLE bcl-2, nm 23 ve c-erbB-2 EKSPRESYONLARI ARASINDAKİ İLİŞKİ

Cerrahpaşa Medical Journal, 2019
Background and Design.- Ovarian cancer is the most common cause of death among all gynecologic malignancies. Genetic alterations important in ovarian tumorigenesis have been identified recently.
Sermin ÖZKAL, Burçin TUNA, Meral KOYUNCUOĞLU, Selma ŞENGİZ, Emek ÖZEN, Turhan USLU   +5 more
doaj  

Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation

, 1998
c-erbB-2, a member of the tyrosine kinase oncogene family, is overexpressed in about 30% of human breast tumors where it correlates with poor prognosis. In vitro studies have suggested that increased expression of the receptor plays an important role in ...
Casalini P., Pupa S. M., De Vecchi R., Giani C., Ardini E., Ménard S., Colnaghi M. I., Giordano A.   +7 more
core   +1 more source