Results 81 to 90 of about 39,006,954 (221)

Distribution of neu (c-erbB-2) Protein in Human Skin

Journal of Investigative Dermatology, 1989
The neu (c-erbB-2) gene encodes a transmembrane protein with tyrosine kinase activity that appears to be a growth factor receptor. Antibody was generated by immunization of rabbits with a synthetic polypeptide that was based on an internal sequence at the carboxy terminus of the molecule.
Maguire, Henry C., Jaworsky, Christine, Cohen, Jeffrey A., Hellman, Maria, Weiner, David B., Greene, Mark I.   +5 more
openaire   +2 more sources

Evaluation of C-ErbB-2 Overexpression and Her-2/neu Gene Copy Number Heterogeneity in Barrett’s Adenocarcinoma

Analytical Cellular Pathology, 2000
Amplifiction of the Her-2/neu gene is accompanied by overexpression of its cell surface receptor product, c‐erbB‐2 protein. To investigate the degree of intratumoural heterogeneity we applied immunohistochemistry in primary Barrett’s adenocarcinoma (BCA)
Axel Walch, Karin Bink, Peter Gais, Stefan Stangl, Peter Hutzler, Michaela Aubele, James Mueller, Heinz Höfler, Martin Werner   +8 more
doaj   +1 more source

Evaluation of the Prevalence of HER-2 Expression and Its Relationship with Prognostic Parameters in Colorectal Carcinoma

İstanbul Medical Journal, 2020
Introduction:Colorectal carcinoma (CRC) is one of the most important causes of cancer-related deaths, and its incidence has been increasing in recent years.
Cansu Benli Işık, Saime Gül Barut
doaj   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Detection of c-erbB-2 amplification in transitional cell bladder carcinoma using competitive PCR technique.

, 1996
We used competitive PCR to verify retrospectively the prognostic significance of c-erbB-2 oncogene amplification in transitional cell bladder carcinomas as a predictive index of patient survival with a maximum follow-up of nine years, and to investigate ...
G. Vona, Pinzani P, Sestini R, Vona G, Giacca M, Pinzani, Pamela, Bianchi, Simonetta, Pazzagli, Mario, M. Pazzagli, C. Selli, R. Sestini, Orlando C, Pazzagli M, Orlando, Claudio, GIACCA, MAURO, C. Orlando, Bianchi S, S. Bianchi, Sestini, Roberta, Vona, Giovanna, SELLI, CESARE, P. Pinzani   +21 more
core   +1 more source

Relationship between XRCC1 protein, miR-7, c-erbB-2 gene expression levels and radiotherapy resistance in non-small cell lung cancer

Zhongguo linchuang yanjiu
Objective To analyze the relationship between XRCC1 protein, miR-7, c-erbB-2 gene expression and radiotherapy resistance in non-small cell lung cancer (NSCLC) and their predictive value.
MA Tingting, ZHOU Liqing, SU Xinyu, XIA Jianhong, YAN Yan
doaj   +1 more source

In vitro study on human cytomegalovirus affecting early pregnancy villous EVT's invasion function

Virology Journal, 2011
Background Human cytomegalovirus (HCMV) is the most common pathogen in uterus during pregnancy, which may lead to some serious results such as miscarriage, stillbirth, cerebellar malformation, fetus developmental retardation, but its pathogenesis has not
Juan Xiao, Zongzhi Yin, Juanjuan Chen, Suhua Chen, Tao Liu, Dandan Zhang   +5 more
doaj   +1 more source

The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV‐positive and in EBV‐negative NPC correlated with genomic alterations and an inflamed microenvironment.
Dara Bracken‐Clarke, Elisabetta Xue, Harris Krause, Tolulope Adeyelu, Mark G. Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P. Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M. Vanderwalde, Andrew Elliott, Conor E. Steuer, Nabil F. Saba, Daniel J. Lubin, Nyall R. London Jr, James L. Gulley, Charalampos S. Floudas   +20 more
wiley   +1 more source

C/EBPbeta-2 confers EGF-independent growth and disrupts the normal acinar architecture of human mammary epithelial cells

Molecular Cancer, 2005
Background The transcription factor, C/EBPbeta, is a key regulator of growth and differentiation in the mammary gland. There are three different protein isoforms of C/EBPbeta. C/EBPbeta-1 and -2 are transactivators, and differ by only 23 N-terminal amino
Sealy Linda, Wells Sam, Bundy Linda
doaj   +1 more source

Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT AKT (protein kinase B, PKB) coordinates the balance between anabolic and catabolic signaling in skeletal muscle through distinct ubiquitin chain types. Some E3 ubiquitin ligases (E3s) and deubiquitinases (DUBs) form stable binary complexes via non‐catalytic interfaces, adding a regulatory layer unavailable to either enzyme alone.
Rajesh Dabur
wiley   +1 more source