Results 51 to 60 of about 53,609 (266)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molekulare Veränderungen beim Pankreaskarzinom [PDF]
, 2018 Zusammenfassung: Grundlagen: Das Pankreaskarzinom hat eine infauste Prognose. Die Ursachen für das aggressive Tumorwachstum und die frühe Metastasierung sind nur unzureichend bekannt.
Berberat, P., Büchler, M., Friess, H.
core
Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast [PDF]
, 2015 Background: Metastases to the breast from extramammary malignancies are very rare, and ruling out the diagnosis of primary breast tumor is important in order to decide on clinical management and predict prognosis.
Derme, Martina +5 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
c-erbB-2 Oncoprotein Content in Gastric Cancer and in Adjacent Mucosa
The International Journal of Biological Markers, 2000 The aim of this study was to evaluate, by means of an immunoenzymatic assay, the membranous and cytosolic c-erbB-2 oncoprotein contents in primary tumors and in adjacent mucosa from gastric cancer patients.
I. García +6 more
doaj +1 more source
Oral contraceptive use and salivary C-erbB-2, CEA and CA15-3 in healthy women : a case-control study [PDF]
, 2011 Objectives: Oral contraceptives (OCP) are highly effective, safe and widely used. Higher exposure to endogenous and exogenous estrogens is generally thought to increase the risk of breast cancer. Therefore, this study was conducted to determine if oral
Abdollahzadeh, Shermin +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Limited Prognostic Value of c-erbB-2 Compared to uPA and PAI-1 in Primary Breast Carcinoma
The International Journal of Biological Markers, 2003 In a retrospective study of 488 women with primary breast cancer, after a median follow-up of 10 years, we sought interactions between disease-free survival (DFS) and overall survival (OS) and tumor antigen levels of two components of the plasminogen ...
C. Bouchet +4 more
doaj +1 more source
乳癌における癌遺伝子産物の免疫組織学的検討 : C-erbB-2 product を中心に [PDF]
, 1990 近年， 乳癌において癌遺伝子と予後因子との関連が注目きれているが， 未だ統ーした見解はえられていない 。その手法も核酸レベルで癌遺伝子の増幅， mutation を検出する方法と癌遺伝子産物を検出する方法に大別きれている。我々は， 新鮮凍結切片を用いてc- erbB-2 product, epidermal growthfactor receptor( EGFR), c-myc protein, estrogen receptor( ER） の免疫組織学的検討を行い既に報告しているが， 加えてc ...
田内 克典 +2 more
core +1 more source
c-erbB-2 expression in benign and malignant breast disease [PDF]
British Journal of Cancer, 1988 An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies. Fourteen out of 103 infiltrating ductal carcinomas exhibited positive membrane staining.
Gusterson, BA +8 more
openaire +3 more sources