Salivary biomarker development using genomic, proteomic and metabolomic approaches. [PDF]
, 2012 The use of saliva as a diagnostic sample provides a non-invasive, cost-efficient method of sample collection for disease screening without the need for highly trained professionals.
Bonne, Nicolai J, Wong, David Tw
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Analytical Cellular Pathology, 1998 Amplification and overexpression of the c-erbB-2 oncogene are of prognostic significance in human breast cancer. Overexpression of c-erbB-2 is the result of gene amplification.
Melek Öztürk +4 more
doaj +1 more source
Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients
BMC Cancer, 2006 Background The inactivation of the tumour suppressor gene and activation of the proto-oncogene are the key steps in the development of the human cancer. The p53 and c-erbB-2 are the best examples of it.
Singh Usha +4 more
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The clinical significance of epidermal growth factor receptor (egf-r) in human breast cancer: A review on 5232 patients [PDF]
, 1992 Epidermal growth factor (EGF) is a 53-aminoacid polypeptide (mol wt 6.045 K) that can influence proliferation and differentiation of a wide variety of cells (1–6).
Berns, P.M.J.J. (Els) +3 more
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The International Journal of Biological Markers, 2004 Background The protein encoded by the c-erbB-2 gene is a membrane receptor expressed in a variety of solid human cancers and directly related to poor prognosis.
F.J. Vizoso +8 more
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Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments. [PDF]
PLoS ONE, 2015 EGFR mutation-induced drug resistance has become a major threat to the treatment of non-small-cell lung carcinoma. Essentially, the resistance mechanism involves modifications of the intracellular signaling pathways.
Debby D Wang +4 more
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Trastuzumab (Herceptin (R)): Monoclonal antibody in the treatment of HER2/neu-overexpressing breast cancer in the metastatic and (neo)adjuvant situation [PDF]
, 2006 Trastuzumab (Herceptin (R)) is a humanized monoclonal antibody that specifically targets HER2/neu (human epidermal growth factor receptor-2) breast cancer cells, which are overexpressed in about 25-30% of breast carcinomas.
Bauerfeind, Ingo +7 more
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The International Journal of Biological Markers, 2003 Background Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis.
I. García +5 more
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Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Usefulness of DNA ploidy, AgNORs, PCNA and c-erbB-2 as predictors of prognosis in patients with renal cell carcinoma [PDF]
, 1997 腎細胞癌71例について核DNA ploidy, AgNOR, PCNA, c-erbB-2を測定した.腎細胞癌全体では核DNA ploidy, AgNOR, PCNA, c-erbB-2はいずれも予後予測因子として有用であることが示唆され, grade 2症例においてもPCNAとc-erbB-2は予後予測因子として有用であることが示唆されたSeventy one patients with renal cell carcinomas were examined for a variety of ...
出口, 隆 +3 more
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