Results 21 to 30 of about 112,287,737 (220)

Changes in c‐erbB‐2 Immunoexpression in Feline Endometrial Adenocarcinomas [PDF]

Reproduction in Domestic Animals, 2015
ContentsHuman epidermal growth factor receptor type 2 (c‐erbB‐2), an oncoprotein with potential prognostic marker and therapeutic use, is overexpressed in several human and animal tumours. But information regarding this molecule in feline tumours is scarce.
Saraiva, Ana Laura da Silva Santos, Gärtner, Fátima, Faria, Fátima, Lourenço, Lígia M., Pires, Maria dos Anjos, Payan-Carreira, Rita   +5 more
openaire   +3 more sources

Alterations of c-Myc and c-erbB-2 genes in ovarian tumours [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Introduction. According to clinical and epidemiological studies, ovarian cancer ranks fifth in cancer deaths among women. The causes of ovarian cancer remain largely unknown but various factors may increase the risk of developing it, such as age, family ...
Pastor Tibor, Popović Branka, Gvozdenović Ana, Boro Aleksandar, Petrović Bojana, Novaković Ivana, Puzović Dragana, Luković Ljiljana, Milašin Jelena   +8 more
doaj   +1 more source

An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]

, 2002
The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
core   +2 more sources

Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation [PDF]

, 1998
c-erbB-2, a member of the tyrosine kinase oncogene family, is overexpressed in about 30% of human breast tumors where it correlates with poor prognosis. In vitro studies have suggested that increased expression of the receptor plays an important role in ...
Casalini P., Pupa S. M., De Vecchi R., Giani C., Ardini E., Ménard S., Colnaghi M. I., Giordano A., S M Pupa, P Casalini, C Giani, M I Colnaghi, E Ardini, A Giordano, R De Vecchi, S Ménard   +15 more
core   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources

Detection of c-erbB-2 mRNAs Using Dig-Labelled Oligonucleotide Probe with in situ Hybridisation in Human Breast Carcinoma: Comparison with Immunohistochemical Results

Analytical Cellular Pathology, 1998
Amplification and overexpression of the c-erbB-2 oncogene are of prognostic significance in human breast cancer. Overexpression of c-erbB-2 is the result of gene amplification.
Melek Öztürk, Sema Bolkent, Selma Yilmazer, Gültekin Kaner, Hilal Ünal   +4 more
doaj   +1 more source

Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients

BMC Cancer, 2006
Background The inactivation of the tumour suppressor gene and activation of the proto-oncogene are the key steps in the development of the human cancer. The p53 and c-erbB-2 are the best examples of it.
Singh Usha, Garbyal RS, Tewari Mallika, Chaube Amita, Shukla Hari S   +4 more
doaj   +1 more source

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Cell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera, Franco Izzo, María F. Chervo, Agustina Dupont, Violeta A. Chiauzzi, Sofia Bruni, Ezequiel Petrillo, Sharon S. Merin, Mara De Martino, Diego Montero, Claudio Levit, Gabriel Lebersztein, Fabiana Anfuso, Agustina Roldán Deamicis, María F. Mercogliano, Cecilia J. Proietti, Roxana Schillaci, Patricia V. Elizalde, Rosalía I. Cordo Russo   +18 more
doaj   +1 more source

C-erbB-2 immunostaining: problems with interpretation. [PDF]

Journal of Clinical Pathology, 1994
AIMS--To assess the consistency and reproducibility of assessment of c-erbB-2 immunostaining, and to examine some of the problems relating to inter- and intraobserver variability in the documentation of positive staining; to profile the spectrum of cytoplasmic and membranous staining in a wide range of tumour types.
E W, Kay, C J, Walsh, M, Cassidy, B, Curran, M, Leader   +4 more
openaire   +2 more sources

Membranous Levels of C-Erbb-2 Oncoprotein in Gastric Cancer: Their Relationship with Clinicopathological Parameters and Their Prognostic Significance

The International Journal of Biological Markers, 2004
Background The protein encoded by the c-erbB-2 gene is a membrane receptor expressed in a variety of solid human cancers and directly related to poor prognosis.
F.J. Vizoso, M.D. Corte, A. Alvarez, I. García, J.M. del Casar, M. Bongera, L.O. Gonzílez, J.L. García-Muñiz, M.T. Allende   +8 more
doaj   +1 more source