Results 161 to 170 of about 105,861 (299)

Late-Stage Aromatic C-H Bond Functionalization for Cysteine/Selenocysteine Bioconjugation. [PDF]

J Am Chem Soc
Zhao Z, Huang J, Cai Y, Zhou TP, Khatib F, Shimon D, Wang B, Metanis N.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Nile Red-Based Covalent Organic Framework as a Photocatalyst for C-H Bond Functionalization. [PDF]

ACS Catal
Gordo-Lozano M, Matesanz DG, Martínez-Fernández M, Almendros P, Martínez-Periñán E, Segura JL, Cembellín S.   +6 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

β-C-H bond functionalization of ketones and esters by cationic Pd complexes. [PDF]

Nature
Li YH, Chekshin N, Lu Y, Yu JQ.
europepmc   +1 more source

Functionalization of C-H bond in superacid

, 2021
In recent years, the exploitation of the functionalization of C-H bonds has made great progress. This methodology is becoming one of the main challenges in organic chemistry due to the selectivity and synthetic opportunities it offers, especially for late-stage functionalization.The exploitation of superacidic conditions for the functionalization of C ...
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Lewis Base-Enhanced C-H Bond Functionalization Mediated by a Diiron Imido Complex. [PDF]

Inorg Chem
Gwinn RK, Latendresse TP, Beck ON, Slebodnick C, Mayhall NJ, Casaday CE, Thornton DA.   +6 more
europepmc   +1 more source

Remote CH Bond Functionalizations

, 2023
Korvorapun, Korkit, Samanta, Ramesh C., Rogge, Torben, Ackermann, Lutz, Maiti, Debabrata, Guin, Srimanta   +5 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source