Results 201 to 210 of about 43,345 (260)

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Highly stereoselective synthesis of allylic β-lactams <i>via</i> enzymatic C(sp³)-H amidation. [PDF]

Chem Sci
Jafari NZ, Wang Z, Chattopadhyay A, Roy S, Fasan R.   +4 more
europepmc   +1 more source

Correction: Enantioselective C(sp³)-H bond functionalization enabled by Cp ^<i>x</i> M(iii) catalysis (M = Co, Rh, Ir). [PDF]

Chem Sci
Mou SB, Luo MP, Fang F, Cao S, Wu D, Wang SG.   +5 more
europepmc   +1 more source

Enantioselective C(sp³)-H bond functionalization enabled by Cp ^<i>x</i> M(iii) catalysis (M = Co, Rh, Ir). [PDF]

Chem Sci
Mou SB, Luo MP, Fang F, Cao S, Wu D, Wang SG.   +5 more
europepmc   +1 more source

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Organocatalysis in Inert C–H Bond Functionalization

Chemical Reviews, 2017
As two coexisting and fast-growing research fields in modern synthetic chemistry, the merging of organocatalysis and C-H bond functionalization is well foreseeable, and the joint force along this line has been demonstrated to be a powerful approach in making inert C-H bond functionalization more viable, predictable, and selective.
Yan Qin, Lihui Zhu, Sanzhong Luo
openaire   +4 more sources

C-H Bond Functionalization in Complex Organic Synthesis

Science, 2006
Direct and selective replacement of carbon-hydrogen bonds with new bonds (such as C–C, C–O, and C–N) represents an important and long-standing goal in chemistry. These transformations have broad potential in synthesis because C–H bonds are ubiquitous in organic substances. At the same time, achieving selectivity among many different C–H bonds remains a
Kamil, Godula, Dalibor, Sames
openaire   +2 more sources

C−H Bond Functionalization by Mechanochemistry

Chemistry – A European Journal, 2017
AbstractThe advances made in the mechanosynthesis of inorganic and organometallic complexes and the excellent past developments with metal‐catalyzed cross‐coupling reactions by high‐speed ball milling have sufficienly laid the ground work for the merging of C−H functionalization and mechanochemical techniques.
openaire   +2 more sources

1.3 C—H Bond Functionalization

2017
AbstractThis chapter deals with C—H bond functionalization catalyzed by N-heterocyclic carbene transition-metal complexes. The C—H bond functionalizations have been classified with respect to the hybridization of the carbon atom and the reaction type.
M. Elie, J.-L. Renaud, S. Gaillard
openaire   +1 more source

CH Bond Functionalization through Intramolecular Hydride Transfer

Angewandte Chemie International Edition, 2014
AbstractKnown for over a century, reactions that involve intramolecular hydride‐transfer events have experienced a recent resurgence. Undoubtedly responsible for the increased interest in this research area is the realization that hydride shifts represent an attractive avenue for CH bond functionalization.
Michael C, Haibach, Daniel, Seidel
openaire   +2 more sources