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Food Frontiers, Volume 7, Issue 6, November 2026.ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source
Neuroscience, 2007 The c-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in ischemic brain injury. The d-retro-inverso form of c-Jun N-terminal kinase-inhibitor (D-JNKI1), a cell-permeable inhibitor of JNK, powerfully reduces neuronal death induced by ...
Gianluigi Forloni +2 more
exaly +2 more sources
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Inhibitors of c-Jun-N-Terminal Kinase (JNK).
Mini-Reviews in Medicinal Chemistry, 2008Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural ...
Theodore M Kamenecka, Philip Lograsso
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c-Jun N-terminal kinase signaling in cellular senescence
Archives of Toxicology, 2023Cellular senescence leads to decreased tissue regeneration and inflammation and is associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the mechanisms of cellular senescence are not fully understood. Emerging evidence has indicated that c-Jun N-terminal kinase (JNK) signaling is involved in the regulation of cellular ...
Ying Deng +7 more
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Inhibitors of c-Jun N-Terminal Kinases: An Update
Journal of Medicinal Chemistry, 2014The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus other kinases has been achieved within the past 4 years.
Koch, Pierre +2 more
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c-Jun N-terminal kinase pathways in diabetes
The International Journal of Biochemistry & Cell Biology, 2008Type 2 diabetes develops from insulin resistance and has become a worldwide epidemic. The c-Jun N-terminal kinases have been considered as signaling molecules linking inflammation and insulin resistance. Genetic disruption of c-Jun N-terminal kinase-1 gene prevents the development of insulin resistance in obese and diabetic mice.
Ruojing, Yang, James M, Trevillyan
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c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase
Archives of Biochemistry and Biophysics, 2006CTP:phosphocholine cytidylyltransferase (CCTalpha) is a rate-regulatory enzyme required for phosphatidylcholine (PtdCho) synthesis. CCTalpha is also a phosphoenzyme, but the physiologic role of kinases on enzyme function remains unclear. We report high-level expression of two major isoforms of the c-Jun N-terminal kinase family (JNK1 and JNK2) in ...
Alan J, Ryan +3 more
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Mechanistic characterization for c-jun-N-Terminal Kinase 1α1
Archives of Biochemistry and Biophysics, 2008c-jun-N-terminal kinase 1alpha1 (JNK1alpha1) is a serine/threonine kinase of the mitogen-activated protein (MAP) kinase family that phosphorylates protein transcription factors after activation by a variety of environmental stressors. In this study, the kinetic mechanism for JNK1alpha1 phosphorylation of activating transcription factor 2 (ATF2) was ...
Brian, Ember, Philip, LoGrasso
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c-Jun N-terminal kinases in memory and synaptic plasticity
revneuro, 2011Abstract The c-Jun N-terminal kinases (JNK) belong to the subfamily of mitogen-activated protein kinases (MAPK). JNK is an important signaling enzyme that is involved in many facets of cellular regulation including gene expression, cell proliferation and programmed cell death. Activation of JNK isoforms (JNK1, 2, and 3) is regarded as
Sherrin, Tessi +2 more
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