Results 251 to 260 of about 31,613,878 (290)

c-Jun N-Terminal Kinase is Upregulated in Patients With Hypospadias

Urology, 2013
To investigate the expression of c-Jun N-terminal kinase (JNK) 1/2 in human hypospadiac tissue compared with that in normal penile tissue.Penile skin tissue specimens obtained at surgery during hypospadias repair or during elective circumcision were divided into 3 groups according to the position of the urethral meatus: children with mild hypospadias ...
Mingyong, Li, Lin, Qiu, Tao, Lin, Dawei, He, Yi, Hua, Xingang, Yuan, Xing, Liu, Guanghui, Wei   +7 more
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Analysis of c-Jun N-Terminal Kinase Regulation and Function

2002
Mitogen-activated protein (MAP) kinase signal transduction pathways coordinate appropriate cellular responses to signals from the extracellular environment. These pathways play significant roles in a diverse set of physiological processes including cellular proliferation, cellular differentiation, oncogenic transformation, programmed cell death, and ...
J Perry, Hall, Roger J, Davis
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Nitric Oxide Modulates the c-Jun N-terminal Kinase/Stress-Activated Protein Kinase Activity through Activating c-Jun N-Terminal Kinase Kinase

Biochemistry, 1997
Nitric oxide is a signaling molecule that has a broad range of physiological functions, including neurotransmission, macrophage activation, and vasodilation. The mechanism by which nitric oxide regulates signal transduction mediating diverse biological activities is not fully understood, however.
H, Kim, J, Shim, P L, Han, E J, Choi
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c-Jun N-terminal kinase – c-Jun pathway transactivates Bim to promote osteoarthritis

Canadian Journal of Physiology and Pharmacology, 2014
Osteoarthritis (OA) is a chronic degenerative joint disorder. Previous studies have shown abnormally increased apoptosis of chondrocytes in patients and animal models of OA. TNF-α and nitric oxide have been reported to induce chondrocyte ageing; however, the mechanism of chondrocyte apoptosis induced by IL-1β has remained unclear.
Zhiqiang, Ye, Yuxian, Chen, Rongkai, Zhang, Haitao, Dai, Chun, Zeng, Hua, Zeng, Hui, Feng, Gengheng, Du, Hang, Fang, Daozhang, Cai   +9 more
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c-Jun N-terminal kinases as potential therapeutic targets

Expert Opinion on Therapeutic Targets, 2007
One principal aim of research in the signal transduction field is to identify targets for therapeutic intervention, in an attempt to modify disease and curtail human suffering. Diseases such as chronic inflammation, atherosclerosis, diabetes and cancer exact a huge toll on health, in physical, social and financial terms.
openaire   +2 more sources

Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy

Biochemical and Biophysical Research Communications, 2007
The mechanisms for diabetic embryopathy are not well understood. JNK1/2 activation is increased in diabetic embryopathy, and antioxidants abolish JNK activation, and thus, ameliorate diabetic embryopathy. Phosphorylated SEK1 were significantly elevated in malformed embryos from diabetic mouse.
Peixin, Yang, Zhiyong, Zhao, E Albert, Reece   +2 more
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Specific activities of individual c-Jun N-terminal kinases in the brain

Neuroscience, 2009
The c-Jun N-terminal kinases (JNKs) are multifunctional molecules which, on the one hand, regulate various processes in brain development, repair and memory formation. On the other hand, JNKs are potent effectors of neuronal death and neuroinflammation.
W, Haeusgen, R, Boehm, Y, Zhao, T, Herdegen, V, Waetzig   +4 more
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c-Jun N-Terminal Kinase Pathway Inhibition in Intracerebral Hemorrhage

Cerebrovascular Diseases, 2010
<i>Background:</i> Inhibition of the c-Jun N-terminal kinase (JNK) pathway by the TAT-coupled peptide XG-102 (formerly D- JNKI1) induces strong neuroprotection in ischemic stroke in rodents. We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH).
Michel-Monigadon, Delphine, Bonny, Christophe, Hirt, Lorenz   +2 more
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The Role of c‐Jun N‐Terminal Kinase (JNK) in Parkinson's Disease

IUBMB Life, 2003
AbstractGiven the critical role that the c‐Jun N‐terminal kinase (JNK) pathway plays in regulating many of the cellular processes which are affected in Parkinson's disease (PD), the possible importance of JNK in disease pathogenesis is being increasingly recognized.
Jun, Peng, Julie K, Andersen
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Inhibitors of c-Jun N-Terminal Kinase 3

2020
The serine/threonine kinase c-Jun N-terminal kinase (JNK) 3 is implicated in the pathogenesis of various disorders ranging from neurodegenerative diseases to inflammation, metabolic disease, diabetes, liver diseases, and cancer. Although the number of publications reporting on JNK3 inhibitors has been decreasing in the last few years, this enzyme still
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