Results 231 to 240 of about 31,613,878 (290)

Erratum to activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis. [PDF]

Ann Transl Med
Editorial Office.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, Volume 20, Issue 11, Page 2584-2610, November 2026.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Mesenchymal Stem/Stromal Cells Induce Myeloid-Derived Suppressor Cells in the Bone Marrow via the Activation of the c-Jun N-Terminal Kinase Signaling Pathway. [PDF]

Int J Mol Sci
Lee HJ, Oh JY.
europepmc   +1 more source

METTL7B‐Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression

Cancer Medicine, Volume 15, Issue 11, November 2026.
In PTC cells, METTL7B stabilizes PLEKHA4 mRNA through m6A modification; upregulated PLEKHA4 binds KLHL12 and inhibits KLHL12‐mediated ubiquitination and degradation of AURKA, thereby stabilizing AURKA protein. Elevated AURKA suppresses ferroptosis by upregulating GPX4 and xCT while downregulating ACSL4, leading to ferroptosis resistance and enhanced ...
Wei Lin, Kunlin Wu, Jinshu Chen, Zhaomei Yu, Huihao Zhang, Xiangjin Chen   +5 more
wiley   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Therapeutic Potential of Propolis in Ulcerative Colitis: A Review of Preclinical Evidence

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review compiles preclinical evidence from studies that investigate the therapeutic potential of propolis extracts derived from different botanical origins, as well as their main bioactive constituents, in the context of ulcerative colitis. The observed beneficial effects are primarily attributed to their antioxidant, immunomodulatory, and anti ...
Thayná Fernandes Barros, Gabriel Gomes Vila Nova, Rosane Nassar Meireles Guerra, Flavia Raquel Fernandes do Nascimento, Afonso Gomes Abreu   +4 more
wiley   +1 more source

Curcumin Intervention in Diabetic Neuropathy: Molecular Mechanisms and Preclinical Insights

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review highlights curcumin's neuroprotective potential, showing how it mitigates oxidative stress and inflammation by modulating Nrf2, MAPK, and NF‐κB signaling. Preclinical data shows it stabilizes glucose metabolism and reduces nerve degradation.
Sanket Sharma, Rosaline Mishra, Rashmi Singh, Radha Goel, Praveen Kumar Gaur, Kanak Lata   +5 more
wiley   +1 more source

Pan‐Adrenergic Inhibition Alleviates Post‐Hemorrhagic Hydrocephalus by Attenuating Neutrophil Extracellular Traps‐Mediated Glymphatic Dysfunction

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Intraventricular hemorrhage induces an adrenergic response that activates PI3K/AKT/mTOR signaling and promotes neutrophil extracellular trap (NET) formation, impairing glymphatic clearance and aggravating post‐hemorrhagic hydrocephalus (PHH). Pan‐adrenergic inhibition after hemorrhage reduced PI3K/AKT/mTOR activation and NET formation, preserved AQP4 ...
Yijian Yang, Yanjie Zhou, Qian Ouyang, Hanati Nuerlanbieke, Yexin Yuan, Junqiang Wang, Kaiyue Wang, Peng Long, Yifeng Chen, Zhikun Liu, Jun Huang, Zhiping Zhang, Zhangjie Su, Xia Wang, Gelei Xiao   +14 more
wiley   +1 more source

HDAC3 drives type II alveolar epithelial barrier dysfunction via MKP1 deacetylation in radiation‐induced lung injury

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
HDAC3 promotes radiation‐induced lung injury by deacetylating MKP1 and activating the p38/c‐Fos/AP‐1 signalling axis, leading to excessive inflammatory responses and alveolar epithelial barrier dysfunction. Targeting HDAC3 with genetic deletion or RGFP966‐mediated inhibition effectively alleviates lung injury, supporting HDAC3 as a promising ...
Boyang Li, Ning Li, Rui Xiong, Yifan Zuo, Yi Liu, Guoqing Luo, Wenjun Zhang, Zhuya Xiao, Long Wu, Min Peng   +9 more
wiley   +1 more source