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c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis
Pulmonary Pharmacology & Therapeutics, 2007Eosinophils are considered to play an important role in the pathogenesis of asthma. Glucocorticoids are potent anti-inflammatory agents for the treatment of chronic inflammatory diseases and they have been shown to increase the rate of eosinophil apoptosis.
Hannele, Hasala +4 more
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Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein
Journal of Neurochemistry, 1997Abstract: A proportion of the neuronal microtubule‐associated protein (MAP) τ is highly phosphorylated in foetal and adult brain, whereas the majority of τ in the neurofibrillary tangles of Alzheimer's patients is hyperphosphorylated; many of the phosphorylation sites are serines or threonines followed by prolines.
C H, Reynolds +4 more
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Analysis of c-Jun N-Terminal Kinase Regulation and Function
2002Mitogen-activated protein (MAP) kinase signal transduction pathways coordinate appropriate cellular responses to signals from the extracellular environment. These pathways play significant roles in a diverse set of physiological processes including cellular proliferation, cellular differentiation, oncogenic transformation, programmed cell death, and ...
J Perry, Hall, Roger J, Davis
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Inhibitors of c-Jun N-Terminal Kinase 3
2020The serine/threonine kinase c-Jun N-terminal kinase (JNK) 3 is implicated in the pathogenesis of various disorders ranging from neurodegenerative diseases to inflammation, metabolic disease, diabetes, liver diseases, and cancer. Although the number of publications reporting on JNK3 inhibitors has been decreasing in the last few years, this enzyme still
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Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development
Targeted Oncology, 2016Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical for developing novel chemoprevention and targeted therapies.
Juan, Wang, Guixiang, Tai
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c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening strategies following studies that have shown their critical roles in the development of a number of diseases, such as diabetes, neurodegeneration and liver disease. We discuss
Bogoyevitch, Marie A. +4 more
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Small Molecule JNK (c-Jun N-Terminal Kinase) Inhibitors
Journal of Medicinal Chemistry, 2010M Arshad, Siddiqui, Panduranga A, Reddy
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Signal transduction by the c-Jun N-terminal kinase.
Biochemical Society symposium, 1999The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAP kinases) is activated by exposure of cells to environmental stress and by the treatment of cells with cytokines. The mechanism of activation of JNK is mediated by dual phosphorylation within kinase subdomain VIII on the motif Thr-Pro-Tyr.
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