c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes [PDF]
Frontiers in Immunology, 2020 Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors.
Claire Imbratta +3 more
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c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy [PDF]
Cell Reports, 2023 Summary: Corticospinal tract (CST) neurons innervate the deep spinal dorsal horn to sustain chronic neuropathic pain. The majority of neurons targeted by the CST are interneurons expressing the transcription factor c-Maf.
Noémie Frezel +12 more
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Transcription factor c-Maf: a checkpoint that programs autoimmunity [PDF]
Frontiers in ImmunologyThe transcription factor c-Maf, a member of the Maf family characterized by its basic domain and b-Zip DNA-binding motif, is a pivotal regulator of immune cells development and function.
Na Liu +10 more
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Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2 [PDF]
JCI Insight, 2023 The transcription factor c-Maf has been widely studied and has been reported to play a critical role in embryonic kidney development; however, the postnatal functions of c-Maf in adult kidneys remain unknown as c-Maf–null C57BL/6J mice exhibit embryonic ...
Mitsunori Fujino +8 more
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Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf [PDF]
Frontiers in Immunology, 2017 c-Maf belongs to the large Maf family of transcription factors and plays a key role in the regulation of cytokine production and differentiation of TH2, TH17, TFH, and Tr1 cells.
Jhang-Sian Yu +5 more
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Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis [PDF]
Cell Communication and Signaling, 2021 Background The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance.
Tong Sun +7 more
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Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple Myeloma [PDF]
MedCommMultiple myeloma (MM), as an incurable hematologic malignancy, is driven by chromosomal translocations. Recent research suggests that targeting phase separation may offer a new therapeutic vulnerability for MM.
Ze Wang +11 more
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PLZF controls the expression of a limited number of genes essential for NKT cell function [PDF]
Frontiers in Immunology, 2012 Natural killer (NKT) T cells exhibit tissue distribution, surface phenotype, and functional responses that are strikingly different from those of conventional T cells.
Michael eGleimer +2 more
doaj +7 more sources
B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma [PDF]
Journal for ImmunoTherapy of CancerBackground The role of B cells in antitumor immunity remains controversial, with studies suggesting the protumor and antitumor activity. This controversy may be due to the heterogeneity in B cell populations, as the balance among the subtypes may impact ...
Hong Li +8 more
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Endothelial c-Maf prevents MASLD-like liver fibrosis by regulating chromatin accessibility to suppress pathogenic microvascular cell subsets [PDF]
JHEP ReportsBackground & Aims: Liver sinusoidal endothelial cells (LSECs) are highly specialized components of the hepatic vascular niche, regulating liver function and disease pathogenesis through angiocrine signaling.
Manuel Winkler +19 more
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