Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia [PDF]
PeerJ, 2021 Background Schizophrenia is a severely multifactorial neuropsychiatric disorder, and the majority of cases are due to genetic variations. In this study, we evaluated the genetic association between the C-Maf-inducing protein (CMIP) gene and schizophrenia
Yingli Fu +6 more
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The Enigmatic Emerging Role of the C-Maf Inducing Protein in Cancer [PDF]
Diagnostics, 2021 The C-Maf-Inducing protein (CMIP) was first described as overexpressed in T cell subpopulations of idiopathic nephrotic syndrome (INS) patients. Later, it was found concomitantly upregulated in podocytes. CMIP expression has also been reported in several
Mario Ollero, Dil Sahali
doaj +6 more sources
Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf. [PDF]
PLoS ONE, 2017 Prostaglandin E2 (PGE2), a major lipid mediator abundant at inflammatory sites, acts as a proinflammatory agent in models of inflammatory/autoimmune diseases by promoting CD4 Th1/Th17 differentiation. Regulatory T cells, including the IL-10 producing Tr1
Kirsten Mary Hooper +2 more
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Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22. [PDF]
PLoS ONE, 2015 C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unknown.
Chih-Chun Liu +9 more
doaj +5 more sources
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function [PDF]
Cell Reports, 2019 Summary: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the
Emily Ling-Lin Pai +13 more
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c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells [PDF]
eLife, 2020 RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian +9 more
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Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling. [PDF]
PLoS Pathogens, 2021 We have recently demonstrated that the function of T follicular helper (Tfh) cells from lymph nodes (LN) of HIV-infected individuals is impaired. We found that these cells were unable to provide proper help to germinal center (GC)-B cells, as observed by
Marita Chakhtoura +10 more
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The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells [PDF]
Frontiers in Immunology, 2017 Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production.
Fabienne Andris +5 more
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c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs. [PDF]
J Exp Med, 2022 Small intestinal villi are structural and functional units present in higher vertebrates and uniquely adapted to nutrient absorption. Villus enterocytes are organized in transcriptional “zones” dedicated to specialized tasks such as absorption of specific nutrients.
González-Loyola A +12 more
europepmc +5 more sources
c-Maf: a bad influence in the education of macrophages. [PDF]
J Clin Invest, 2020 Tumor-associated macrophages (TAMs) represent the most abundant hematopoietic cell type in the solid tumor microenvironment. TAMs drive T cell inhibition, promote angiogenesis, and produce tumor growth factors. Although they can paradoxically exert antitumor activity and prime protective immunity, the pathways driving this phenotype remain unclear.
Conejo-Garcia JR, Rodriguez PC.
europepmc +4 more sources