Results 31 to 40 of about 81,067 (257)

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources

Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells

Frontiers in Immunology, 2020
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota.
Hind Hussein, Sébastien Denanglaire, Frédéric Van Gool, Frédéric Van Gool, Abdulkader Azouz, Yousra Ajouaou, Hana El-Khatib, Guillaume Oldenhove, Oberdan Leo, Fabienne Andris   +9 more
doaj   +1 more source

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]

, 2014
During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Kaech, Susan M, Laidlaw, Brian J, Lang, Philipp A, Marshall, Heather D, Ohashi, Pamela, Parish, Ian A, Perry, Curtis, Staron, Matthew M, Tsui, Yao-Chen, Weaver, Casey T   +12 more
core   +1 more source

c-Maf and you won’t see fat [PDF]

Journal of Clinical Investigation, 2010
Osteoporosis is a common, age-related bone disease that results from an imbalance between the processes of bone formation and bone resorption, resulting in reduced bone mass and increased risk of fracture. Mesenchymal stem cells have the capacity to differentiate into osteoblastic and adipogenic lineages; recent research suggests that the switch ...
openaire   +2 more sources

MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice [PDF]

, 2018
The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues. Previous studies have shown that MAFB is expressed in embryonic and adult mouse testes and is expected to act as the downstream ...
Abdellatif Ahmed M., Basha Walaa A., El-Shemy Hany A., Hasegawa Kazunori, Kitadate Yu, Mochida Keiji, Muratani Masafumi, Ogura Atsuo, Oishi Hisashi, Okada Risa, Shawki Hossam H., Takahashi Satoru, Usui Toshiaki, Yoshida Shosei, 岡田 理沙, 村谷 匡史, 高橋 智   +16 more
core   +5 more sources

Carbon Isotopic Signature and Organic Matter Composition of Cenomanian High-Latitude Paleosols of Southern Patagonia

Geosciences, 2021
The Cenomanian Mata Amarilla Formation (MAF) in southern Patagonia (~55° S paleolatitude, Austral-Magallanes Basin, Argentina) is composed mainly of stacked fluvial deposits with intercalated paleosols, which document Cenomanian environments at high ...
Augusto Nicolás Varela, María Sol Raigemborn, Patricio Emmanuel Santamarina, Sabrina Lizzoli, Thierry Adatte, Ulrich Heimhofer   +5 more
doaj   +1 more source

Evolution of microstructure and mechanical properties of Ti-based metal-matrix composites during hot deformation [PDF]

MATEC Web of Conferences, 2020
Two Ti-based composites, viz. Ti/TiB and Ti-15Mo/TiB were produced by spark plasma sintering using a Ti-10wt.%TiB2 powder mixture at 1000°C or Ti-14.25(wt.)%Mo-5(wt.)%TiB2 powder mixture at 1400°C, respectively.
Zherebtsov S., Ozerov M., Klimova M., Klimenko D., Sokolovsky V., Stepanov N.   +5 more
doaj   +1 more source

SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes. [PDF]

J Clin Invest, 2018
SUMOylation is involved in the development of several inflammatory diseases, but the physiological significance of SUMO-modulated c-Maf in autoimmune diabetes is not completely understood. Here, we report that an age-dependent attenuation of c-Maf SUMOylation in CD4+ T cells is positively correlated with the IL-21-mediated diabetogenesis in NOD mice ...
Hsu CY, Yeh LT, Fu SH, Chien MW, Liu YW, Miaw SC, Chang DM, Sytwu HK.   +7 more
europepmc   +4 more sources

TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines

Haematologica, 2007
Background and Objectives BAFF and APRIL stimulate the growth of multiple myeloma (MM) cells. BAFF and APRIL share two receptors – TACI and BCMA – and BAFF binds to a third receptor, BAFF-R.
Jérôme Moreaux, Dirk Hose, Michel Jourdan, Thierry Reme, Michael Hundemer, Marion Moos, Nicolas Robert, Philippe Moine, John De Vos, Hartmut Goldschmidt, Bernard Klein   +10 more
doaj   +1 more source

Transcript-indexed ATAC-seq for precision immune profiling. [PDF]

, 2018
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D, Chang, Howard Y, Corces, M Ryan, Davis, Mark M, Gennert, David G, Granja, Jeffrey M, Greenleaf, William J, Khavari, Paul A, Khodadoust, Michael S, Kim, Youn H, Lareau, Caleb A, Li, Rui, Mumbach, Maxwell R, Parker, Kevin R, Qi, Yanyan, Rubin, Adam J, Saligrama, Naresha, Satpathy, Ansuman T, Schep, Alicia N, Serratelli, William S, Wei, Yuning, Wu, Beijing   +21 more
core   +1 more source