Results 31 to 40 of about 82,350 (159)
Frontiers in Immunology, 2020 RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota.
Hind Hussein +9 more
doaj +1 more source
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]
, 2014 During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne +12 more
core +1 more source
c-Maf and you won’t see fat [PDF]
Journal of Clinical Investigation, 2010 Osteoporosis is a common, age-related bone disease that results from an imbalance between the processes of bone formation and bone resorption, resulting in reduced bone mass and increased risk of fracture. Mesenchymal stem cells have the capacity to differentiate into osteoblastic and adipogenic lineages; recent research suggests that the switch ...
openaire +2 more sources
Geosciences, 2021 The Cenomanian Mata Amarilla Formation (MAF) in southern Patagonia (~55° S paleolatitude, Austral-Magallanes Basin, Argentina) is composed mainly of stacked fluvial deposits with intercalated paleosols, which document Cenomanian environments at high ...
Augusto Nicolás Varela +5 more
doaj +1 more source
Evolution of microstructure and mechanical properties of Ti-based metal-matrix composites during hot deformation [PDF]
MATEC Web of Conferences, 2020 Two Ti-based composites, viz. Ti/TiB and Ti-15Mo/TiB were produced by spark plasma sintering using a Ti-10wt.%TiB2 powder mixture at 1000°C or Ti-14.25(wt.)%Mo-5(wt.)%TiB2 powder mixture at 1400°C, respectively.
Zherebtsov S. +5 more
doaj +1 more source
MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice [PDF]
, 2018 The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues. Previous studies have shown that MAFB is expressed in embryonic and adult mouse testes and is expected to act as the downstream ...
Abdellatif Ahmed M. +16 more
core +5 more sources
Haematologica, 2007 Background and Objectives BAFF and APRIL stimulate the growth of multiple myeloma (MM) cells. BAFF and APRIL share two receptors – TACI and BCMA – and BAFF binds to a third receptor, BAFF-R.
Jérôme Moreaux +10 more
doaj +1 more source
SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes. [PDF]
J Clin Invest, 2018 SUMOylation is involved in the development of several inflammatory diseases, but the physiological significance of SUMO-modulated c-Maf in autoimmune diabetes is not completely understood. Here, we report that an age-dependent attenuation of c-Maf SUMOylation in CD4+ T cells is positively correlated with the IL-21-mediated diabetogenesis in NOD mice ...
Hsu CY +7 more
europepmc +4 more sources
Clinical implications of c-maf expression in plasma cells from patients with multiple myeloma
Experimental Hematology & Oncology, 2017 Background Multiple myeloma (MM) is a type of hematological malignancy with significant heterogeneity in clinical features and prognosis. Cytogenetic abnormalities are the major factors affecting patient outcomes.
GuoQing Wei +13 more
doaj +1 more source
The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
Frontiers in Immunology, 2017 Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production.
Fabienne Andris +5 more
doaj +1 more source