eLife, 2020 Maf (c-Maf) and Mafb transcription factors (TFs) have compensatory roles in repressing somatostatin (SST+) interneuron (IN) production in medial ganglionic eminence (MGE) secondary progenitors in mice.
Emily Ling-Lin Pai +10 more
doaj +1 more source
Transcript-indexed ATAC-seq for precision immune profiling. [PDF]
, 2018 T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D +21 more
core +1 more source
Induction of peripheral tolerance in ongoing autoimmune inflammation requires interleukin 27 signaling in dendritic cells [PDF]
, 2017 Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells.
Mari, Elisabeth R. +3 more
core +2 more sources
Carbon Capture Science & Technology, 2023 A profound and accelerated solution towards mitigating atmospheric CO2 levels and converting the CO2 to useful fuels and chemicals, such as CO or CH4, would be to utilize and promote the catalytic CO2 hydrogenation reaction.
Pradeep S. Murthy +4 more
doaj +1 more source
Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy. [PDF]
PLoS ONE, 2018 We investigated whether polymorphisms (SNPs) in the promoter region of TNFA, or in the autoinflammatory TNFRSF1A and MEFV genes, concur with HLA-B27 in enhancing the risk of Spondyloarthritis (SpA) and/or in predicting the response to anti-TNFα treatment.
Ada Aita +9 more
doaj +1 more source
MafB is a critical regulator of complement component C1q [PDF]
, 2017 The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages.
Andrea Christina-Sylvia +24 more
core +1 more source
WaveCNV: allele-specific copy number alterations in primary tumors and xenograft models from next-generation sequencing. [PDF]
, 2013 MotivationCopy number variations (CNVs) are a major source of genomic variability and are especially significant in cancer. Until recently microarray technologies have been used to characterize CNVs in genomes.
Ali, Johar +11 more
core +3 more sources
Journal of Materials Research and TechnologyThe effect of microstructure and mechanical properties of submicro grained commercial pure titanium (CP–Ti) on the wear mechanism is still unclear.
Rongyou Chen +9 more
doaj +1 more source
Polarisation of Tumor-Associated Macrophages toward M2 Phenotype Correlates with Poor Response to Chemoradiation and Reduced Survival in Patients with Locally Advanced Cervical Cancer. [PDF]
PLoS ONE, 2015 We investigate the prognostic role of pre-treatment ratio between Type 1 (M1) and Type 2 (M2) tumor-associated macrophages (TAMs) in locally advanced cervical cancer (LACC) patients treated with chemoradiation (CT/RT).84 consecutive LACC patients treated
Marco Petrillo +7 more
doaj +1 more source
Regulation of Lens Fiber Cell Differentiation by Transcription Factor c-Maf [PDF]
Journal of Biological Chemistry, 1999 To elucidate the regulatory mechanisms underlying lens development, we searched for members of the large Maf family, which are expressed in the mouse lens, and found three, c-Maf, MafB, and Nrl. Of these, the earliest factor expressed in the lens was c-Maf.
S, Kawauchi +7 more
openaire +2 more sources