Results 31 to 40 of about 288,633 (118)

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2018
Background The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy ...
Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero   +5 more
doaj   +1 more source

Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation. [PDF]

PLoS ONE, 2014
Nowadays, drug resistance still represents a major obstacle to successful acute myeloid leukemia (AML) treatment and the underlying mechanism is not fully elucidated. Here, we found that high expression of c-Myc was one of the cytogenetic characteristics
Xiao-Na Pan, Jia-Jie Chen, Le-Xun Wang, Ruo-Zhi Xiao, Ling-Ling Liu, Zhi-Gang Fang, Quentin Liu, Zi-Jie Long, Dong-Jun Lin   +8 more
doaj   +1 more source

PA2G4 Functions as a Cofactor for MYC Family Oncoproteins in MYC-Driven Malignancies

Cells
MYCN and c-MYC are critical driver oncogenes in several childhood cancers, including neuroblastoma. Currently, the clinical development of MYC inhibitors has been hindered by the intrinsically disordered structure of MYC proteins, which lack well-defined
Sukriti Krishan, Jessica Koach, Taylor Lim, Kenny Yeo, Faith Cheong, Jie-Si Luo, Hassina Massudi, Xiaomian Gao, Sopheakwealthy Heangsarath, Andrew J. Kueh, Marco J. Herold, Belamy B. Cheung, Glenn M. Marshall   +12 more
doaj   +1 more source

DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein

Molecular Cancer, 2008
Background C-Myc is a short-lived oncoprotein that is destroyed by ubiquitin-mediated proteolysis. Dysregulated accumulation of c-Myc commonly occurs in human cancers. Some of those cases with the dysregulated c-Myc protein accumulation are attributed to
Wang Yu, Shang Zeng-Fu, Huo Yan-Ying, Zhang Shi-Meng, Xu Qin-Zhi, Yang Dong-Yan, An Jing, Wu De-Chang, Zhou Ping-Kun   +8 more
doaj   +1 more source

C-MYC aberrations as prognostic factors in diffuse large B-cell lymphoma: a meta-analysis of epidemiological studies.

PLoS ONE, 2014
ObjectivesVarious studies have investigated the prognostic value of C-MYC aberrations in diffuse large B-cell lymphoma (DLBCL). However, the role of C-MYC as an independent prognostic factor in clinical practice remains controversial. A systematic review
Kuangguo Zhou, Danmei Xu, Yang Cao, Jue Wang, Yunfan Yang, Mei Huang   +5 more
doaj   +1 more source

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

Cell Death and Disease, 2021
Dysregulation of transforming growth factor-beta (TGFβ) signaling has been implicated in liver carcinogenesis with both tumor promoting and inhibiting activities.
Haichuan Wang, Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen   +8 more
doaj   +1 more source

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer

Frontiers in Genetics
BackgroundProto-oncogenes are abnormally activated in nearly all types of tumors. However, the epigenetic mechanism of proto-oncogene activation has not yet been well elucidated.MethodsThe present study involved the construction of a double-stranded cDNA
Xuming Hu, Xuming Hu, Xuming Hu, Ye Wei, Meiying Zhang, Chunfeng Dou, Liping Wang, Gul Zaib, Huixian Wu, Wang Guo, Xiaoyuan Wang, Shihao Chen, Qi Xu, Qi Xu, Qi Xu, Mingzhou Guo, Hengmi Cui, Hengmi Cui, Hengmi Cui, Hengmi Cui   +19 more
doaj   +1 more source

LINC01963 promotes pancreatic ductal adenocarcinoma proliferation via METTL3/IGF2BP2 axis-mediated m⁶A modification of c-Myc

Journal of Experimental & Clinical Cancer Research
Background C-Myc overexpression is an important molecular hallmark of pancreatic ductal adenocarcinoma (PDAC), but directly targeting c-Myc is extremely challenging.
Qixian Liu, Ruiyu Li, Bohan Liu, Hangqi Liu, Xuqing Shi, Xianglin Yin, Xinping Ju, Sichong Zhang, Jun Wang, Yuhan Zhang, Xiaoding Liu, Dongmei Li, Longyun Chen, Yamei Niu, Huanwen Wu, Zhiyong Liang   +15 more
doaj   +1 more source

c-Myc Inhibition Induces an Additive Effect with Cyclophosphamide in Acute Lymphoblastic Leukemia [PDF]

ImmunoAnalysis
Background: Cellular-myelocytomatosis (c-Myc), an oncoprotein and a transcription factor, is involved in several essential cellular processes. The c-Myc expression level is highly regulated in normal cells.
Mohammad Sadeghi, Maryam Panahi, Zahra Kheyrizadeh, Leili Aghebati-Maleki, Ali Akbar Movasaghpour Akbari, Abbas Ali Hosseinpour Feizi, Sima Shahmohammadi Farid, Sanam Dolati, Farhad Jadidi-Niaragh   +8 more
doaj   +1 more source

Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand

Journal of Nucleic Acids, 2011
The indolocarbazole derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) has demonstrated a high potency (at nanomolar to submicromolar concentrations) towards the NCI panel of human tumor cell lines and transplanted ...
Dmitry N. Kaluzhny, Anna K. Shchyolkina, Nikolay S. Ilyinsky, Olga F. Borisova, Alexander A. Shtil   +4 more
doaj   +1 more source