Results 21 to 30 of about 20,867,404 (313)

Target c-Myc to treat pancreatic cancer

Cancer Biology & Therapy, 2022
C-Myc overexpression is a common finding in pancreatic cancer and predicts the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby regulating their transcription.
Moein Ala
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A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability

Oncogene, 2021
The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, the underlying mechanism is not fully understood.
Pengpeng Zhu, F. He, Yixuan Hou, G. Tu, Qiao Li, T. Jin, Huan Zeng, Yilu Qin, Xueying Wan, Yina Qiao, Yuxiang Qiu, Yong Teng, Man-Ran Liu   +12 more
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Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

Scientific Reports, 2023
c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear.
Takahiro Masaki, Makoto Habara, Shunsuke Hanaki, Yuki Sato, Haruki Tomiyasu, Yosei Miki, Midori Shimada   +6 more
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Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

Cell Communication and Signaling, 2022
Background Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance.
Ruosi Yao, Menghui Zhang, Jian Zhou, Linlin Liu, Yan Zhang, Jian Gao, Kailin Xu   +6 more
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Rabring7 degrades c-Myc through complex formation with MM-1. [PDF]

PLoS ONE, 2012
We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of ...
Rina Narita, Hirotake Kitaura, Ayako Torii, Erika Tashiro, Makoto Miyazawa, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga   +6 more
doaj   +1 more source

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

Molecular Cancer, 2020
c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this
S. Madden, A. D. de Araujo, Mara Gerhardt, D. Fairlie, J. Mason   +4 more
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Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc

International Journal of Hyperthermia, 2022
Background Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. Objective We hypothesized that
Xiaole Li, Shichao Duan, Yingjuan Zheng, Yongqiang Yang, Lei Wang, Xinqiang Li, Qing Zhang, Rick F. Thorne, Wencai Li, Daoke Yang   +9 more
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c-Myc accelerates S-phase and requires WRN to avoid replication stress. [PDF]

PLoS ONE, 2009
c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown.
Kristin Robinson, Nichaya Asawachaicharn, Denise A Galloway, Carla Grandori   +3 more
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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Cell, 2011
SUMMARY MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist.
Jake E. Delmore, Ghayas C. Issa, M. Lemieux, P. Rahl, Junwei Shi, H. Jacobs, E. Kastritis, Timothy Gilpatrick, Ronald M. Paranal, J. Qi, M. Chesi, A. Schinzel, M. McKeown, T. Heffernan, Christopher R. Vakoc, P. Bergsagel, I. Ghobrial, P. Richardson, R. Young, W. Hahn, K. Anderson, A. Kung, J. Bradner, C. Mitsiades   +23 more
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PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression

Theranostics, 2020
The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the mechanisms underlying c-Myc-mediated gene repression in the context of cancer remain less clear.
Ming Liu, Bing Yao, T. Gui, Chan Guo, Xiaobing Wu, Jia-Huang Li, Lingling Ma, Yexuan Deng, Pei-Pei Xu, Ying Wang, Dong-Jun Yang, Qixiang Li, Xiang-Wei Zeng, Xinyu Li, Ruifeng Hu, Jing-Ru Ge, Zenong Yu, Yu-Gen Chen, Bing Chen, Junyi Ju, Quan Zhao   +20 more
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