Results 41 to 50 of about 20,867,404 (313)
Expression of proto-oncogene c-Myc in patients with urinary bladder transitional cell carcinoma
Current Urology, 2021 . Background:. c-Myc is a proto-oncogene located on human chromosome 8. It encodes a transcriptional factor which regulates the expression of approximately 10% to 15% of human genes, playing a crucial role in cell growth, differentiation, cellular ...
Charalampos Fragkoulis +7 more
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Neoplasia: An International Journal for Oncology Research, 2006 BACKGROUND: Deregulation of c-myc plays a major role in the carcinogenesis of human malignancies. We investigated the amplification of the c-myc gene in a surgical series of Barrett cancers. METHODS: Primary resected esophageal (Barrett) adenocarcinomas (
Burkhard H.A. von Rahden +3 more
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Frontiers in Pharmacology, 2021 Background: Identifying patients with de novo acute myeloid leukemia (AML) who will probably respond to the “7 + 3” induction regimen remains an unsolved clinical challenge.
Tzu-Hung Hsiao +15 more
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Transcriptional Amplification in Tumor Cells with Elevated c-Myc
Cell, 2012 Summary Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome.
Charles Y. Lin +7 more
semanticscholar +1 more source
The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. [PDF]
PLoS ONE, 2012 p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription.
Chang Kyoo Sung +8 more
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c-Myc Suppression of DNA Double-strand Break Repair
Neoplasia: An International Journal for Oncology Research, 2012 c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s)
Zhaozhong Li +8 more
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IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Nature Communications, 2019 Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy.
Xia Sheng +15 more
semanticscholar +1 more source
Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions [PDF]
Genes & Cancer, 2010 The coding region determinant binding protein, CRD-BP, is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. It is mostly expressed in fetal and neonatal tissues, where it regulates many transcripts essential for normal embryonic development.
Felicite K, Noubissi +3 more
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Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis [PDF]
Oncogene, 2000 Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression.
T L, Timme +7 more
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FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity [PDF]
Journal of Biological Chemistry, 2015 FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood.
Zhichao, Mei +5 more
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