Results 151 to 160 of about 19,933,051 (310)

lncRNA ch-MYC-AS1 restricts ALV-J replication by disrupting the ANXA2-C-Myc oncogenic axis

Microbiology Spectrum
The c-Myc oncogene is a critical regulator of viral oncogenesis and immune evasion in multiple cancers. However, its modulation by long noncoding RNAs (lncRNAs) during retroviral infection remains poorly understood. Here, we show that ch-MYC-AS1, a novel
Suyu Fan, Weiyi Zhou, Xuming Hu, Yingjie Gu, Guangzhong Peng, Yu Zhang, Wenming Zhao, Guohong Chen, Qi Xu   +8 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

C-myc Expression in the Microvessels of Medulloblastoma

Collegium antropologicum, 2011
The increased expression of c-myc is related to neoplastic transformation and angiogenesis. Therefore, the assessment of expression of c-myc in endothelial cells and neovascularization could help to determine the biological behavior of the tumor. We analyzed neovascularization and c-myc expression in 36 medulloblastoma specimens. The results were shown
Stanić, Gabrijela, Čupić, Hrvoje, Žarković, Kamelija, Tomas, Davor, Krušlin, Božo   +4 more
openaire   +4 more sources

A] c-Myc iperexpression (2+); B] absence of expression of c-Myc.

, 2015
A] c-Myc iperexpression (2+); B] absence of expression of c-Myc.
Liang Cheng (228343), Enrico Munari (750218), Matteo Brunelli (295531), Alessandra Modena (750219), Giampaolo Tortora (295546), Isabella Sperduti (85365), Chiara Ciccarese (612004), Valentina Zambonin (750220), Francesco Massari (295545), Walter Artibani (57676), Guido Martignoni (295553), Emilio Bria (295532)   +11 more
core   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Importance of copy number alterations of FGFR1 and c-MYC genes in triple negative breast cancer [PDF]

Journal of Medical Biochemistry, 2019
Background: Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and is unresponsive to anti-HER2 and endocrine therapy. TNBC is difficult to treat and is often lethal.
Nedeljković Milica, Tanić Nikola, Dramićanin Tatjana, Milovanović Zorka, Šušnjar Snežana, Milinković Vedrana, Vujović Ivana, Prvanović Mirjana, Tanić Nasta   +8 more
doaj  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

, 2008
SummaryMyc activity is emerging as a key element in acquisition and maintenance of stem cell properties. We have previously shown that c-Myc deficiency results in accumulation of defective hematopoietic stem cells (HSCs) due to niche-dependent ...
Blanco-Bose, William E., Cheng, P.F., Cheng, Pei-Feng, Ehninger, A., Wilson, A., MacDonald, H.R., Bernstein, I.D., Laurenti, E., Ferrero, I., Eisenman, R.N., Bernstein, Irwin D., Laurenti, Elisa, Knoepfler, P.S., Trumpp, Andreas, Ferrero, Isabel, Trumpp, A., Eisenman, Robert N., Varnum-Finney, B., MacDonald, H. Robson, Varnum-Finney, Barbara, Wilson, Anne, Ehninger, Armin, Knoepfler, Paul S., Blanco-Bose, W.E., Bernstein ID, Knoepfler PS, Trumpp A, Varnum-Finney B, Eisenman RN, Ehninger A, MacDonald HR, Ferrero I, Cheng PF, Wilson A, Laurenti E, Blanco-Bose WE   +35 more
core   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source