Rabring7 degrades c-Myc through complex formation with MM-1. [PDF]
PLoS ONE, 2012 We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of ...
Rina Narita +6 more
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Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc
International Journal of Hyperthermia, 2022 Background Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. Objective We hypothesized that
Xiaole Li +9 more
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c-Myc accelerates S-phase and requires WRN to avoid replication stress. [PDF]
PLoS ONE, 2009 c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown.
Kristin Robinson +3 more
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Global regulation of nucleotide biosynthetic genes by c-Myc. [PDF]
PLoS ONE, 2008 The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes.
Yen-Chun Liu +8 more
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Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner. [PDF]
PLoS ONE, 2013 The transcription factors Runx1 and c-Myc have individually been shown to regulate important gene targets as well as to collaborate in oncogenesis. However, it is unknown whether there is a regulatory relationship between the two genes. In this study, we
Paejonette T Jacobs +6 more
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Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. [PDF]
PLoS ONE, 2011 BACKGROUND: During limb development, chondrocytes and osteoblasts emerge from condensations of limb bud mesenchyme. These cells then proliferate and differentiate in separate but adjacent compartments and function cooperatively to promote bone growth ...
Zi-Qiang Zhou +5 more
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Integration of genome and chromatin structure with gene expression profiles to predict c-MYC recognition site binding and function. [PDF]
PLoS Computational Biology, 2007 The MYC genes encode nuclear sequence specific-binding DNA-binding proteins that are pleiotropic regulators of cellular function, and the c-MYC proto-oncogene is deregulated and/or mutated in most human cancers. Experimental studies of MYC binding to the
Yili Chen +5 more
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Myc interacts with Max and Miz1 to repress C/EBPδ promoter activity and gene expression
Molecular Cancer, 2010 Background "Loss of function" alterations in CCAAT/Enhancer Binding Proteinδ (C/EBPδ) have been reported in a number of human cancers including breast, prostate and cervical cancer, hepatocellular carcinoma and acute myeloid leukemia.
Yu Xueyan +3 more
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Expression of proto-oncogene c-Myc in patients with urinary bladder transitional cell carcinoma
Current Urology, 2021 . Background:. c-Myc is a proto-oncogene located on human chromosome 8. It encodes a transcriptional factor which regulates the expression of approximately 10% to 15% of human genes, playing a crucial role in cell growth, differentiation, cellular ...
Charalampos Fragkoulis +7 more
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c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer. [PDF]
PLoS ONE, 2015 The aim of this study was to determine the incidence and clinicopathological significance of c-MYC gene copy-number (GCN) gain in patients with primary colorectal cancer (CRC).The c-MYC GCN was investigated in 367 consecutive CRC patients (cohort 1) by ...
Kyu Sang Lee +7 more
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