Results 41 to 50 of about 19,205,329 (382)
Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas, [PDF]
, 2014 Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers.
Cavanè, A +13 more
core +1 more source
c-Myc Suppression of DNA Double-strand Break Repair
Neoplasia: An International Journal for Oncology Research, 2012 c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s)
Zhaozhong Li +8 more
doaj +1 more source
Regulation of c-MYC transcriptional activity by transforming growth factor-beta 1-stimulated clone 22 [PDF]
, 2018 c‐MYC stimulates cell proliferation through the suppression of cyclin‐dependent kinase (CDK) inhibitors including P15 (CDKN2B) and P21 (CDKN1A).
Kato Mitsuyasu +6 more
core +2 more sources
Frontiers in Pharmacology, 2021 Background: Identifying patients with de novo acute myeloid leukemia (AML) who will probably respond to the “7 + 3” induction regimen remains an unsolved clinical challenge.
Tzu-Hung Hsiao +15 more
doaj +1 more source
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Nature Communications, 2019 Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy.
Xia Sheng +15 more
semanticscholar +1 more source
Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]
, 2014 This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Frenzel, Anna +7 more
core +3 more sources
Apoptotic signaling by c-MYC [PDF]
Oncogene, 2008 c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes cells to apoptosis by a variety of stimuli. The decision of a cell to undergo apoptosis and how this apoptotic response is regulated by c-MYC depends on the specific cell type and ...
B, Hoffman, D A, Liebermann
openaire +2 more sources
International Journal of Molecular Sciences, 2019 Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism, and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can become a promising therapeutic target molecule in cancer.
M. Elbadawy +3 more
semanticscholar +1 more source
Expressão de c-myc em lesões mamárias associadas a microcalcificações detectadas por mamografia de rotina [PDF]
, 2009 CONTEXT AND OBJECTIVE: Genetic abnormalities in cell proliferation-regulating genes have been described in premalignant lesions. The aims here were to evaluate c-myc protein expression in non-palpable breast lesions associated with microcalcifications ...
Elias, Simone +4 more
core +2 more sources
c-MYC-Induced Genomic Instability [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor initiation. Early studies using MYC-carrying retroviruses showed that these viruses were potent transforming agents. Cell culture models followed that addressed the role of MYC in transformation.
Alexandra, Kuzyk, Sabine, Mai
openaire +2 more sources