Results 71 to 80 of about 19,205,329 (382)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions [PDF]

Genes & Cancer, 2010
The coding region determinant binding protein, CRD-BP, is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. It is mostly expressed in fetal and neonatal tissues, where it regulates many transcripts essential for normal embryonic development.
Felicite K, Noubissi, Mikhail A, Nikiforov, Nancy, Colburn, Vladimir S, Spiegelman   +3 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2018
Background The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy ...
Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero   +5 more
doaj   +1 more source

Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation. [PDF]

PLoS ONE, 2014
Nowadays, drug resistance still represents a major obstacle to successful acute myeloid leukemia (AML) treatment and the underlying mechanism is not fully elucidated. Here, we found that high expression of c-Myc was one of the cytogenetic characteristics
Xiao-Na Pan, Jia-Jie Chen, Le-Xun Wang, Ruo-Zhi Xiao, Ling-Ling Liu, Zhi-Gang Fang, Quentin Liu, Zi-Jie Long, Dong-Jun Lin   +8 more
doaj   +1 more source

LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance We report in this article that c-Myc-mediated repression of lncRNA IDH1-AS1 sustains activation of the Warburg effect by HIF1α under normoxic conditions.
S. Xiang, Hao Gu, Lei Jin, R. Thorne, Xu Dong Zhang, Mian Wu   +5 more
semanticscholar   +1 more source

Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis [PDF]

Oncogene, 2000
Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression.
T L, Timme, A, Goltsov, S, Tahir, L, Li, J, Wang, C, Ren, R N, Johnston, T C, Thompson   +7 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells [PDF]

, 2002
The objective of this article is to dissect the mechanisms by which the down-regulation of c-Myc induces programmed cell death in melanoma cells.
Annamaria Biroccio, Askew, Backway, Barbara Benassi, Bello-Fernandez, Biroccio, Biroccio, Chiba, Citro, Curtin, Desbarats, Dong, Evan, Franklin, Freedman, Fruehauf, Fruehauf, Gabriella Zupi, Galaktionov, Ghibelli, Ghibelli, Ghibelli, Giovanna Chiorino, Giuseppe Filomeni, Giuseppe Rotilio, Hermeking, Hoang, Jacobson, Kimura, Leonetti, Leonetti, Liu, Macho, Marcu, Maria Rosa Ciriolo, Meister, Menssen, Nesbit, Nesbit, Pena, Pierce, Reed, Sarah Amodei, Seelig, Sergio Marchini, Shim, Shim, Skorski, Um, van den Dobbelsteen, Van Waardenburg, Wagner, Wonsey   +52 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source