Results 221 to 230 of about 69,600 (248)

Significant difference of c-type lectin-like receptor 2 between colorectal cancer and polyp subgroups

Cancer Biomarkers, 2021
BACKGROUND: Platelets play a key role in tumor progression and metastasis. C-type lectin-like receptor 2 (CLEC-2) is the receptor expressed on platelets and the marker of platelet activation. OBJECTIVE: This study aims to determine whether soluble CLEC-2 levels differ between patients with benign colorectal polyps and those with colorectal cancer (CRC).
Meng-Lin, Zhang, Wen-Juan, Huang, Chen-Xi, Yue, Ming-Ming, Li, Na, Li, Rui-Tao, Wang, Rui, Xie   +6 more
openaire   +2 more sources

Screening for Ligands of C-Type Lectin-Like Receptors

2011
In order to execute their immune functions, leukocytes interact with a broad range of cell types through cell surface receptors, such as those of the immunoglobulin and C-type lectin families, or indirectly through soluble factors. The characterization of activating and inhibitory counterparts of NK cell receptors on myeloid cells, as well as the ...
Elwira, Pyż, Gordon D, Brown
openaire   +2 more sources

The production of soluble C-type lectin-like receptor 2 is a regulated process

Glycoconjugate Journal, 2012
C-type lectin-like receptor 2 (CLEC-2) is a newly identified type II transmembrane protein belonging to the C-type lectin family molecules, which acts as a cell-surface receptor for snake venom toxin rhodocytin and tumor antigen podoplanin. We previously demonstrated that the full-length mouse CLEC-2 (mCLEC-2) can be cleaved into soluble form. Elevated
Min, Fei, Lei, Zhou, Jianhui, Xie, Yuanyuan, Ruan, Jiejie, Xu, Songbin, He, Hongjie, Shen, Yumin, Hu, Shifang, Ren, Changgeng, Ruan   +9 more
openaire   +2 more sources

Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma

Journal of Bone and Mineral Research, 2020
ABSTRACT The overall prognosis of patients with sarcoma-based cancers has changed little in the last 20 years. There is an urgent need to investigate the metastatic potential of these tumors and to develop anti-metastatic drugs. It is becoming increasingly clear that platelets play an important role in the establishment of metastasis ...
Jiro Ichikawa, Takashi Ando, Tomonori Kawasaki, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Yujiro Kimura, Kaoru Aoki, Keiko Hayakawa, Katsue Suzuki-Inoue, Masao Saitoh, Hirotaka Haro   +11 more
openaire   +2 more sources

C-Type Lectin-Like Receptor 2 (CLEC-2)

2016
C-type lectin-like receptor 2 (CLEC-2) has been identified as a receptor for a platelet-activating snake venom, rhodocytin. CLEC-2 elicits powerful platelet activation signals in a manner dependent on Src, Syk kinases, and phospholipase Cγ2, similar to the collagen receptor glycoprotein (GP) VI/FcRγ-chain complex.
openaire   +1 more source

The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions

Journal of Proteomics, 2019
The cytotoxicity of mouse natural killer (NK) cells in response to pathological changes in target cells is regulated via the Nkrp1b receptor. Here, we characterized the Nkrp1b structure and structural features (stalk, loop, and oligomerization state) that affect its interactions.
Hernychová, Lucie, Rosůlek, Michal, Kádek, Alan, Mareška, Václav, Chmelík, Josef, Adámková, Ljubina, Grobárová, Valéria, Šebesta, Ondřej, Kukačka, Zdeněk, Skála, Kristián, Spiwok, Vojtěch, Černý, Jan, Novák, Petr   +12 more
openaire   +2 more sources

The C-type lectin-like receptors of Dectin-1 cluster in natural killer gene complex

Glycoconjugate Journal, 2012
Natural killer gene complex (NKC) encodes a group of proteins with a single C-type lectin-like domain, (CTLD) which can be subdivided several subfamilies according to their structures and expression patterns. The receptors containing the conserved calcium binding sites in the CTLD fold belong to group II of C-type lectin superfamily and are expressed ...
openaire   +2 more sources

Platelet c-type lectin-like receptor reduces cholestatic liver injury in mice

Journal of Hepatology, 2018
S. Maruyama, H. Kono, S. Furuya, D. Ichikawa   +3 more
openaire   +1 more source

Natural killer lectin-like receptors have divergent carboxyl-termini, distinct from C-type lectins

Immunogenetics, 1994
T V, Adamkiewicz, C, McSherry, F H, Bach, J P, Houchins   +3 more
openaire   +2 more sources

C-Type Lectin-Like Receptor 2

2018
openaire   +1 more source