Results 51 to 60 of about 157,346 (209)
, 2016 C-type lectins, originally defined as proteins binding carbohydrates in a Ca(2+)-dependent manner, form a large family containing soluble and membrane-bound proteins. Among them, those expressed on phagocytes and working as pathogen pattern-recognition receptors were designated as C-type lectin receptors (CLRs), in accordance with Toll-like receptors ...
openaire +2 more sources
Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins.
PLoS Pathogens, 2021 In C. elegans, 283 clec genes encode a highly diverse family of C-type lectin-like domain (CTLD) proteins. Since vertebrate CTLD proteins have characterized functions in defense responses against pathogens and since expression of C. elegans clec genes is
Barbara Pees +10 more
doaj +1 more source
Inhibitory C-type lectin receptors in myeloid cells
Immunology Letters, 2011 C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally ...
Redelinghuys, Pierre, Brown, Gordon D
openaire +4 more sources
C-Type Lectin Receptors in Antiviral Immunity and Viral Escape
Frontiers in Immunology, 2018 C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses. However,
Marta Bermejo-Jambrina +7 more
doaj +1 more source
Levels of complexity in pathogen recognition by C-type lectins
Current Opinion in Immunology, 2005 In pathogen recognition by C-type lectins, several levels of complexity can be distinguished; these might modulate the immune response in different ways. Firstly, the pathogen-associated molecular pattern repertoire expressed at the microbial surface determines the interactions with specific receptors.
Cambi, A., Figdor, C.G.
openaire +5 more sources
BMC Immunology, 2012 Background CD72 is an inhibitory co-receptor expressed on B cells. We previously demonstrated significant association of the polymorphism of the CD72 gene with susceptibility to human systemic lupus erythematosus (SLE) in individuals carrying a SLE ...
Hitomi Yuki +5 more
doaj +1 more source
C-type lectins in immunity to Mycobacterium tuberculosis
Frontiers in Bioscience, 2011 Tuberculosis (TB) remains one of the leading causes of death due to a single infectious agent, Mycobacterium tuberculosis, with nearly 2 million deaths per year (1). Most individuals exposed to the bacillus develop a nonpathological form, latent TB, with only a small minority (5 to 10%) developing active disease.
Olivier Neyrolles, Antoine Tanne
openaire +3 more sources
Detection of CLEC5A-JEV Interaction by ELISA
Bio-Protocol, 2012 JEV (Japanese encephalitis virus) belonging to Flaiviridae interacts with CLEC5A (C-type lectin domain family 5, member A), a member of C-type lectin associated with DAP12 signaling protein and expressed on myeloid cell, as the same extent as Dengue ...
Szu-Ting Chen, Shie-Liang Hsieh
doaj +1 more source
Frontiers in Immunology, 2017 Surfactant protein D (SP-D) is a soluble C-type lectin, belonging to the collectin (collagen-containing calcium-dependent lectin) family, which acts as an innate immune pattern recognition molecule in the lungs at other mucosal surfaces.
Eswari Dodagatta-Marri +11 more
doaj +1 more source
Frontiers in Immunology, 2019 Numerous bacterial pathogens infect the mammalian host by initially associating with epithelial cells that line the intestinal lumen. Recent work has revealed that commensal bacteria that reside in the intestine promote defense against pathogenic ...
Vivienne Woo +5 more
doaj +1 more source