Results 31 to 40 of about 108,848 (254)

An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides

Journal for ImmunoTherapy of Cancer, 2018
Background Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by ...
Laura L. Eggink, Katherine F. Roby, Robert Cote, J. Kenneth Hoober   +3 more
doaj   +1 more source

Information transfer in mammalian glycan-based communication

eLife, 2023
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger, Dongyoon Kim, Natalia Baranova, Hanka Vrban, Marten Kagelmacher, Robert Wawrzinek, Christoph Rademacher   +6 more
doaj   +1 more source

Inhibitory C-type lectin receptors in myeloid cells

Immunology Letters, 2011
C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally ...
Redelinghuys, Pierre, Brown, Gordon D
openaire   +3 more sources

Signaling C-type lectin receptors in antimycobacterial immunity

PLOS Pathogens, 2017
The mammalian innate immune system is composed of phagocytes such as macrophages and dendritic cells that serve as the first line of defense against microbial infections. These cells express various pattern recognition receptors (PRRs) that recognize specific pathogen-associated molecular patterns (PAMPs) on the surface of or inside microorganisms [1].
Mohlopheni J. Marakalala, Hlumani Ndlovu
openaire   +5 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tailoring the Immune Microenvironment of Dendritic Cells by Targeting C - type Lectin Receptor

Reproductive and Developmental Medicine, 2017
Background: The C-type lectin receptor (CLR) expressed by DCs participates in the recognition and capture of various glycosylated self-antigens and pathogens.
Miao Xiong, Li Li, Yang Liu, Jun Wang, Jie-Ping Zhu   +4 more
doaj   +1 more source

C‐type lectin‐like receptors on myeloid cells

Annals of Medicine, 2006
Host defence against pathogens requires the recognition of conserved microbial molecules, or 'pathogen-associated molecular patterns' (PAMPs), by their receptors termed 'pattern recognition receptors' (PRRs), represented most notably by toll-like receptors (TLRs) and C-type lectins.
Elwira, Pyz, Andrew S J, Marshall, Siamon, Gordon, Gordon D, Brown   +3 more
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human Natural Killer Gene Complex (NKC)

Frontiers in Immunology, 2013
Functional responses of Natural Killer (NK) cells including eradication of ‘harmful’ cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes
Yvonne eBartel, Björn eBauer, Alexander eSteinle   +2 more
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source