Results 101 to 110 of about 17,598 (187)
The Journal of Headache and PainBackground Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management.
Shi-Ze Leng +16 more
doaj +1 more source
Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions. [PDF]
, 2012 International audienceBACKGROUND: Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted ...
Arenzana-Seisdedos, Fernando +11 more
core +4 more sources
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman +2 more
wiley +1 more source
Scientific ReportsGenetic backgrounds of patients with pulmonary arterial hypertension (PAH) were not fully investigated. A variant of c.14429G > A (p.Arg4810Lys) in the ring finger protein 213 gene (RNF213) was recently identified as a risk allele for poor treatment ...
Takahiro Hiraide +11 more
doaj +1 more source
Migration of dendritic cells across blood and lymphatic endothelial barriers. [PDF]
, 2006 7openopenDel Prete A; Locati M; Otero K; Riboldi E; Mantovani A; Vecchi A; Sozzani S.DEL PRETE, Annalisa; Locati, M; Otero, K; Riboldi, E; Mantovani, A; Vecchi, A; Sozzani ...
Del Prete, Annalisa +6 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.Patients with Parkinson's disease showed poorer social cognition overall regardless of gene. There is an interplay between PD, rs2966700, and positive emotion recognition. PD patients carrying the C allele on rs2966700 performed poorer, suspected due to decreased EPHA1‐AS1 activity and increased inflammation.
Yu‐Chen Lin +3 more
wiley +1 more source
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4 [PDF]
, 2017 The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis.
Caucheteux, Stephan +17 more
core +3 more sources
The Role of Macrophage Dynamics in Atherosclerosis Analyzed Using a Petri Net-Based Model
Applied SciencesAtherosclerosis, a chronic inflammatory and oxidative stress-mediated disease impacting the arterial system, stands as a primary cause of morbidity and mortality worldwide.
Agnieszka Rybarczyk +2 more
doaj +1 more source