Results 101 to 110 of about 325,163 (330)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Network Flow Method Integrates Skeleton Information for Multiple C. elegans Tracking

Sensors
In order to solve the issues arising from collisions, this paper proposes a network flow method combined with skeleton information for multiple C. elegans tracking. In the intra-track stage, non-colliding C.
Taoyuan Yu, Xiping Xu, Ning Zhang
doaj   +1 more source

Lipidomic Analysis of Caenorhabditis elegans Embryos

Bio-Protocol, 2017
Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal model for novel
Hung-Chi Yang, Cheng-Yu Hung, Yi-Yun Pan, Szecheng Lo, Daniel Chiu   +4 more
doaj   +1 more source

Isoflurane impairs oogenesis through germ cell apoptosis in C. elegans

Scientific Reports, 2021
Anesthetic isoflurane has been reported to induce toxicity. However, the effects of isoflurane on fecundity remain largely unknown. We established a system in C. elegans to investigate the effects of isoflurane on oogenesis.
Tao Zhang, Cheng Ni, Cheng Li, Pan Lu, Dan Chen, Yuanlin Dong, Johnathan R. Whetstine, Yiying Zhang, Zhongcong Xie   +8 more
doaj   +1 more source

Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans [PDF]

, 2008
Transposable elements may acquire unrelated gene fragments into their sequences in a process called transduplication. Transduplication of protein-coding genes is common in plants, but is unknown of in animals.
Ast, Gil, Makalowski, Wojciech, Pupko, Tal, Sela, Noa, Stern, Adi   +4 more
core   +4 more sources

Neuropeptide GPCRs in C. elegans [PDF]

Frontiers in Endocrinology, 2012
Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools.
Frooninckx, Lotte, Van Rompay, Liesbeth, Temmerman, Liesbet, Van Sinay, Elien, Beets, Isabel, Janssen, Tom, Husson, Steven J., Schoofs, Liliane   +7 more
openaire   +3 more sources

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Multigenome DNA sequence conservation identifies Hox cis-regulatory elements [PDF]

, 2008
To learn how well ungapped sequence comparisons of multiple species can predict cis-regulatory elements in Caenorhabditis elegans, we made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how
De Buysscher, Tristan, DeModena, John A., Kuntz, Steven G., Schwarz, Erich M., Shizuya, Hiroaki, Sternberg, Paul W., Trout, Diane, Wold, Barbara J.   +7 more
core   +3 more sources

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Caenorhabditis elegans for research on cancer hallmarks

Disease Models & Mechanisms, 2023
Julián Cerón
doaj   +1 more source