Results 111 to 120 of about 3,095,271 (376)

MASP-1 Induces a Unique Cytokine Pattern in Endothelial Cells: A Novel Link between Complement System and Neutrophil Granulocytes [PDF]

, 2014
Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this immediate anti-microbial action.
A Krarup, A Mantovani, A Mocsai, A Mocsai, A Tedgui, A Ueda, Attila Mócsai, BK Rada, C Michiels, CI Oie, Csaba I. Tímár, D Heja, D Storm, DY Yuen, E Stylianou, EF Foxman, Erika Kajdácsi, G Ambrus, Ger van Zandbergen, I Kim, I Oynebraten, I Oynebraten, J Dobo, J Dobo, JM Park, JS Presanis, József Dobó, K Futosi, KM Valentijn, Krisztina Futosi, L Knipe, L Martorell, László Cervenak, M Megyeri, M Oroszlan, MG Rondaij, MP Delghandi, Márton Megyeri, N Szabo-Fresnais, NW Lukacs, Péter Gál, Péter K. Jani, QX Niu, R Dewberry, R Shreeniwas, RP Cherla, S Hippenstiel, S Thiel, SR Coughlin, V Bezzerri, V Mako, Veronika Makó, Zoltán Doleschall   +52 more
core   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The effect of C1-esterase inhibitor on systemic inflammation in trauma patients with a femur fracture - The CAESAR study: study protocol for a randomized controlled trial

Trials, 2011
Background Systemic inflammation in response to a femur fracture and the additional fixation is associated with inflammatory complications, such as acute respiratory distress syndrome and multiple organ dysfunction syndrome.
Strengers Paul FW, Koenderman Anky HL, van Wessem Karlijn JP, Visser Tjaakje, Heeres Marjolein, Koenderman Leo, Leenen Luke PH   +6 more
doaj   +1 more source

Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment

Annals medicus, 2016
Uncontrolled generation of bradykinin (BK) due to insufficient levels of protease inhibitors controlling contact phase (CP) activation, increased activity of CP proteins, and/or inadequate degradation of BK into inactive peptides increases vascular ...
S. Zeerleder, M. Levi
semanticscholar   +1 more source

Ceramic Particle‐Reinforced Medium‐Entropy Alloys With Outstanding Mechanical Properties Prepared by Novel Micro‐LPBF

Advanced Functional Materials, EarlyView.
An innovative medium entropy alloy (MEA) composite material was fabricated via micro laser powder bed fusion (μ‐LPBF) with appropriate nano‐ceramic particles doping and exhibited markedly improved overall performance, including synergistically enhanced strength and ductility, increased hardness and compressive strength, improved wear resistance and ...
Zhonglin Shen, Mingwang Fu
wiley   +1 more source

A nationwide study of acquired C1-inhibitor deficiency in France

Medicine, 2016
Acquired angioedema (AAE) due to C1-inhibitor (C1INH) deficiency is rare. Treatment options for acute attacks are variable and used off-label. Successful treatment of the associated lymphoma with rituximab seems to prevent acute attacks in subjects with ...
D. Gobert, R. Paule, D. Ponard, P. Lévy, V. Frémeaux-Bacchi, L. Bouillet, I. Boccon-Gibod, C. Drouet, S. Gayet, D. Launay, Ludovic Martin, A. Mékinian, V. Leblond, O. Fain   +13 more
semanticscholar   +1 more source

Intrabandgap States Engineering in Functionalized Nanodiamond to Generate Solvated Electrons for Photocatalysis Under Solar Illumination

Advanced Functional Materials, EarlyView.
The negative electron affinity of diamond allows to emit highly reductive electrons. By introducing intra‐bandgap states and an optimized electron transfer mechanism by surface functionalization with Ru(bpy)3, the formation of solvated electrons is achieved upon solar irradiation.
Benjamin Kiendl, Arsène Chemin, Adam H. Day, Rocio B. Rodriguez, Sneha Choudhury, Franziska Buchner, Kaan Atak, Christoph Merschjann, Emina Hadzifejzovic, Tim D. W. Claridge, Karin Larsson, Amélie Venerosy, Mailis M. Lounasvuori, Natalia Zabarska, Boyan Iliev, Thomas J. S. Schubert, Hugues A. Girard, Jean‐Charles Arnault, John S. Foord, Tristan Petit, Anke Krueger   +20 more
wiley   +1 more source

Insights into the Purification of C1-esterase Inhibitor from Human Plasma

Plasmatology
Hereditary angioedema (HAE) is a rare but often life-threatening genetic disorder caused by either lack of or dysfunctional C1-esterase inhibitor (C1-I3NH). C1-INH is a high-cost therapy for HAE.
Sachin Verma, Sheetal Dolia, Savan Makadia, Narendra Kumar   +3 more
doaj   +1 more source

Serum MASP-1 in complex with MBL activates endothelial cells. [PDF]

, 2014
The complement system plays an important role in the induction of inflammation. In this study we demonstrate that the initiation complexes of the lectin pathway, consisting of mannose-binding lectin (MBL) and associated serine proteases (MASPs) elicit ...
Ambrus, Balázs Major, Beinrohr, Dahl, Davis, Degn, Degn, Degn, Degn, Dobó, Dobó, Dobó, Endre Schwaner, Erika Kajdácsi, Gulla, Gál, Hansen, Heja, Heja, Hess, Jensenius, János Rigó, József Dobó, Kidmose, Kocsis, László Cervenak, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Márton Megyeri, Møller-Kristensen, Oroszlán, Paréj, Paréj, Péter Gál, Péter K. Jani, Péter Závodszky, Ricklin, Saeed, Skjoedt, Steffen Thiel, Stover, Takahashi, Thiel, Thiel, Thiel, Thiel, Thiel, van der Pol   +50 more
core   +1 more source

Psychometric study of the SF-36v2 in hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) [PDF]

, 2021
Paola Palao-Ocharan, Nieves Prior, Elia Pérez‐Fernández, Magdalena Caminoa, Teresa Caballero   +4 more
openalex   +1 more source